[en] The longitudinal relationship between bone health and muscle health is scarcely explored. We aimed to explore the Relationship between bone decline and muscle decline over 1 year in older individuals. We used data from the SarcoPhAge cohort, which aims to identify the consequences of sarcopenia. In this way, this study also highlights the yearly changes in
muscle mass (by dual-energy absorptiometry), muscle weakness (by grip strength), and/or physical performance (by the short physical performance battery test). Measurements of areal bone mineral density (aBMD), enabling the diagnosis of osteoporosis, and bone microarchitecture (by means of the trabecular bone score) were also performed each year. A 1-year clinically relevant decline in bone and muscle health components was evidenced using the Edwards–Nunnally index. Among the 232 participants with complete data (75.5 ± 5.4 years, 57.8% women), we observed an association between a clinically relevant decline in the skeletal muscle mass index (SMI) and a decrease in aBMD (adjusted OR = 2.12 [1.14–2.51] for the
spine, 2.42 [1.10–5.34] for the hip and 2.12 [1.04–5.81] for the neck), as well as a significant association between SMI and deterioration of the skeletal microarchitecture (aOR = 3.99 [2.07–7.70]). A clinically relevant decline in muscle strength was associated with a decrease in spine aBMD (aOR = 2.93 [1.21–7.12]) and hip aBMD (aOR = 3.42 [1.37–7.64]) only. The decline in muscle performance was related to the decline in bone microarchitecture only (aOR = 2.52 [1.23–5.17]). Individuals with incident sarcopenia had an approximately fivefold higher risk of concomitantly developing osteoporosis. A dynamic relationship between impaired muscle and bone health was observed, with an obvious association between the concomitant incidences of osteoporosis and sarcopenia.
Disciplines :
General & internal medicine
Author, co-author :
Locquet, Médéa ; Université de Liège - ULiège > Département des sciences de la santé publique > Epidémiologie clinique
Beaudart, Charlotte ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Language :
English
Title :
Association between the decline in muscle health and the decline in bone health in older individuals from the SarcoPhAge Cohort.
Cianferotti L, Brandi ML (2014) Muscle–bone interactions: basic and clinical aspects. Endocrine 45:165–177. 10.1007/s12020-013-0026-8
Gielen E, Bergmann P, Bruyère O et al (2017) Osteoporosis in frail patients: a consensus paper of the Belgian bone club. Calcif Tissue Int. 10.1007/s00223-017-0266-3
Reginster J-Y, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38:4–9. 10.1016/j.bone.2005.11.024
Ethgen O, Beaudart C, Buckinx F et al (2017) The future prevalence of sarcopenia in Europe: a claim for public health action. Calcif Tissue Int 100:229–234. 10.1007/s00223-016-0220-9
Bruyère O, Beaudart C, Locquet M et al (2016) Sarcopenia as a public health problem. Eur Geriatr Med. 10.1016/j.eurger.2015.12.002
Kanis JA, McCloskey EV, Harvey NC et al (2015) Intervention thresholds and the diagnosis of osteoporosis. J Bone Miner Res 30:1747–1753. 10.1002/jbmr.2531
Kanis JA, Cooper C, Rizzoli R et al (2017) Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting. Osteoporos Int 28:2023–2034. 10.1007/s00198-017-4009-0
Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423. 10.1093/ageing/afq034
Chen L-K, Liu L-K, Woo J et al (2014) Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15:95–101. 10.1016/j.jamda.2013.11.025
Studenski SA, Peters KW, Alley DE et al (2014) The FNIH sarcopenia project: rationale, study description, conference recommendations, and final estimates. J Gerontol A 69:547–558. 10.1093/gerona/glu010
Morley JE, Abbatecola AM, Argiles JM et al (2011) Sarcopenia with limited mobility: an international consensus. J Am Med Dir Assoc 12:403–409. 10.1016/j.jamda.2011.04.014
Marzetti E, Calvani R, Tosato M et al (2017) Sarcopenia: an overview. Aging Clin Exp Res 29:11–17. 10.1007/s40520-016-0704-5
Locquet M, Beaudart C, Reginster J-Y et al (2017) Prevalence of concomitant bone and muscle wasting in elderly women from the SarcoPhAge cohort: preliminary results. J Frailty Aging 6:18–23. 10.14283/jfa.2016.111
Paintin J, Cooper C, Dennison E (2018) Osteosarcopenia. Br J Hosp Med 79:253–258. 10.12968/hmed.2018.79.5.253
Hirschfeld HP, Kinsella R, Duque G (2017) Osteosarcopenia: where bone, muscle, and fat collide. Osteoporos Int 28:2781–2790. 10.1007/s00198-017-4151-8
Locquet M, Beaudart C, Bruyère O et al (2018) Bone health assessment in older people with or without muscle health impairment. Osteoporos Int 29:1057–1067. 10.1007/s00198-018-4384-1
Tarantino U, Baldi J, Celi M et al (2013) Osteoporosis and sarcopenia: the connections. Aging Clin Exp Res 25:93–95. 10.1007/s40520-013-0097-7
Beaudart C, Reginster JY, Petermans J et al (2015) Quality of life and physical components linked to sarcopenia: the SarcoPhAge study. Exp Gerontol 69:103–110. 10.1016/j.exger.2015.05.003
Roberts HC, Denison HJ, Martin HJ et al (2011) A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing 40:423–429. 10.1093/ageing/afr051
Guralnik JM, Ferrucci L, Pieper CF et al (2000) Lower extremity function and subsequent disability: consistency across studies, predictive models, and value of gait speed alone compared with the short physical performance battery. J Gerontol A 55:M221–M231
Wright NC, Looker AC, Saag KG et al (2014) The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res 29:2520–2526. 10.1002/jbmr.2269
Harvey NC, Glüer CC, Binkley N et al (2015) Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice. Bone 78:216–224. 10.1016/j.bone.2015.05.016
Johansson H, Kanis JA, McCloskey EV et al (2011) A FRAX® model for the assessment of fracture probability in Belgium. Osteoporos Int 22:453–461. 10.1007/s00198-010-1218-1
Guigoz Y, Vellas B, Garry PJ (2009) Assessing the nutritional status of the elderly: the Mini Nutritional Assessment as part of the geriatric evaluation. Nutr Rev 54:S59–S65. 10.1111/j.1753-4887.1996.tb03793.x
Tombaugh TN, McIntyre NJ (1992) The mini-mental state examination: a comprehensive review. J Am Geriatr Soc 40:922–935
Elosua R, Marrugat J, Molina L et al (1994) Validation of the Minnesota leisure time physical activity questionnaire in Spanish men. Am J Epidemiol 139:1197–1209. 10.1093/oxfordjournals.aje.a116966
Speer DC (1992) Clinically significant change: Jacobson and Truax (1991) revisited. J Consult Clin Psychol 60:402–408
Lodder MC, Lems WF, Ader HJ et al (2004) Reproducibility of bone mineral density measurement in daily practice. Ann Rheum Dis 63:285–289. 10.1136/ARD.2002.005678
Imerci A, Yalın Kılınç C, Aydogan NH et al (2017) Fracture Risk Assessment tool (FRAX®) results calculated with and without bone mineral density values for the evaluation of fracture risk in postmenopausal women with osteopenia. J Clin Densitom. 10.1016/j.jocd.2017.06.027
Moreira OC, Oliveira CEP de, De Paz JA (2018) Dual energy X-ray absorptiometry (DXA) reliability and intraobserver reproducibility for segmental body composition measuring. Nutr Hosp 35:340–345. 10.20960/nh.1295
Savva C, Giakas G, Efstathiou M, Karagiannis C (2014) Test-retest reliability of handgrip strength measurement using a hydraulic hand dynamometer in patients with cervical radiculopathy. J Manipulative Physiol Ther 37:206–210. 10.1016/j.jmpt.2014.02.001
Gómez JF, Curcio C-L, Alvarado B et al (2013) Validity and reliability of the short physical performance battery (SPPB): a pilot study on mobility in the Colombian Andes. Colomb Med 44:165–171
Kim KM, Lim S, Oh TJ et al (2018) Longitudinal changes in muscle mass and strength, and bone mass in older adults: gender-specific associations between muscle and bone losses. J Gerontol A 73:1062–1069. 10.1093/gerona/glx188
Kwon S, Perera S, Pahor M et al (2009) What is a meaningful change in physical performance? Findings from a clinical trial in older adults (the LIFE-P study). J Nutr Health Aging 13:538–544
Hans D, Goertzen AL, Krieg M-A, Leslie WD (2011) Bone microarchitecture assessed by TBS predicts osteoporotic fractures independent of bone density: the Manitoba study. J Bone Miner Res 26:2762–2769. 10.1002/jbmr.499
Moon RJ, Cole ZA, Crozier SR et al (2015) Longitudinal changes in lean mass predict pQCT measures of tibial geometry and mineralisation at 6–7 years. Bone 75:105–110. 10.1016/j.bone.2015.02.015
Elkasrawy MN, Hamrick MW (2010) Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact 10:56–63
Yeung SSY, Reijnierse EM, Trappenburg MC et al (2018) Handgrip strength cannot be assumed a proxy for overall muscle strength. J Am Med Dir Assoc 19:703–709. 10.1016/j.jamda.2018.04.019
Harvey NC, Odén A, Orwoll E et al (2018) Measures of physical performance and muscle strength as predictors of fracture risk independent of FRAX, falls and BMD: a meta-analysis of the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res. 10.1002/jbmr.3556
Russo CR, MD (2009) The effects of exercise on bone. Basic concepts and implications for the prevention of fractures. Clin Cases Miner Bone Metab 6:223–228
Wagner P, Chapurlat R, Ecochard R, Szulc P (2018) Low muscle strength and mass is associated with the accelerated decline of bone microarchitecture at the distal radius in older men: the prospective STRAMBO study. J Bone Miner Res. 10.1002/jbmr.3456
Khazzani H, Allali F, Bennani L et al (2009) The relationship between physical performance measures, bone mineral density, falls, and the risk of peripheral fracture: a cross-sectional analysis. BMC Public Health 9:297. 10.1186/1471-2458-9-297
Nielsen BR, Abdulla J, Andersen HE et al (2018) Sarcopenia and osteoporosis in older people: a systematic review and meta-analysis. Eur Geriatr Med 9:419–434. 10.1007/s41999-018-0079-6
Picca A, Calvani R, Manes-Gravina E et al (2018) Bone-muscle crosstalk: unraveling new therapeutic targets for osteoporosis. Curr Pharm Des 23:6256–6263. 10.2174/1381612823666170526112300
Reginster J-Y, Beaudart C, Buckinx F, Bruyère O (2016) Osteoporosis and sarcopenia: two diseases or one? Curr Opin Clin Nutr Metab Care 19:31–36. 10.1097/MCO.0000000000000230
Karsenty G, Ferron M (2012) The contribution of bone to whole-organism physiology. Nature 481:314–320. 10.1038/nature10763
Tagliaferri C, Wittrant Y, Davicco M-J et al (2015) Muscle and bone, two interconnected tissues. Ageing Res Rev 21:55–70. 10.1016/j.arr.2015.03.002
Lam H, Qin Y-X (2008) The effects of frequency-dependent dynamic muscle stimulation on inhibition of trabecular bone loss in a disuse model. Bone. 10.1016/j.bone.2008.07.253
Bonnick SL (2008) Monitoring changes in bone density. Women’s Health 4:89–97. 10.2217/17455057.4.1.89
