Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study.

[en] Objectives: Mediterranean diet has several beneficial effects on health, but data regarding the association between Mediterranean diet and knee osteoarthritis (OA) are limited mainly to cross-sectional studies. We investigated whether higher Mediterranean diet adherence is prospectively associated with lower risk of radiographic OA (ROA), radiographic symptomatic knee OA (SxOA) and pain worsening in North American people at high risk or having knee OA. Methods: Adherence to the Mediterranean diet was evaluated using a validated Mediterranean diet score (aMED), categorized in five categories (Q1 to Q5, higher values reflecting higher adherence to Mediterranean diet). Knee OA outcomes included incident (1) ROA, (2) SxOA, as the new onset of a combination of a painful knee and ROA, (3) knee pain worsening, i.e. a Western Ontario and McMaster Universities Osteoarthritis Index difference between baseline and each annual exam of 14%. Results: 4330 subjects (mean age: 61.1 years; 58.0% females) were included. Based on a multivariable Poisson regression analysis, during a mean follow-up period of 4 years, participants who were more highly adherent to a Mediterranean diet (Q5) reported lower risk of pain worsening (relative risk, RR ¼ 0.96; 95% CI: 0.91e0.999) compared to those in Q1. In 2994 people free from SxOA at baseline, higher adherence to a Mediterranean diet was associated with a lower risk for SxOA during follow-up by 9% (Q5 vs. Q1; RR ¼ 0.91; 95% CI: 0.82e0.998). No significant associations emerged between aMED and incident ROA.

Disciplines :

General & internal medicine

Author, co-author :

Veronese, Nicola

Koyanagi, Ai

Stubbs, Brendon

Cooper, Cyrus

Guglielmi, Giuseppe

Rizzoli, René

Punzi, Leonardo

Rogoli, Domenico

Caruso, Maria Gabriella

Rotolo, Ornella

More authors (5 more)

Language :

English

Title :

Mediterranean diet and knee osteoarthritis outcomes: a longitudinal cohort study.

Publication date :

2019

Journal title :

Clinical Nutrition

ISSN :

0261-5614

eISSN :

1532-1983

Publisher :

Churchill Livingstone, United States

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 December 2018

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