Article (Scientific journals)
Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria.
Straetemans, Saartje; Thomas, Muriel; Craen, Margarita et al.
2018In International Journal of Pediatric Endocrinology, 2018, p. 9
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Keywords :
Children; First-year response; Growth hormone deficiency; Growth hormone treatment; Small for gestational age
Abstract :
[en] Background: There is no consensus on the definition of poor growth response after the first year of growth hormone (GH) treatment. We determined the proportion of poor responders identified by different criteria in children with GH deficiency (GHD) and born small for gestational age (SGA). The second aim was to analyze the IGF-1 response in poor growth responders. Methods: First-year height data of 171 SGA and 122 GHD children who remained prepubertal during the first GH treatment year were retrieved from the BESPEED database and analyzed. Criteria for poor first-year response/responsiveness were: change in height (Ht) SDS<0.3 or<0.5, height velocity (HV) SDS<0.5 or <1 based on the population reference, HV SDS<- 1 based on the KIGS expected HV curve (HV Ranke SDS), studentized residual (SR) <- 1 in the KIGS first-year prediction model. Results: Ht SDS<0.5 gave the highest percentage poor responders (37% SGA, 26% GHD). Although % poor responders were comparable for Ht SDS<0.3, HV SDS<+ 0.5, HV SDS<+ 1, SR<- 1, and HV Ranke SDS<- 1, these criteria did not always identify the same patients as poor responders. Among the poor growth responders 24% SGA and 14% GHD patients had an IGF-1 increase < 40%. Conclusions: The different response criteria yield high but comparable percentages poor responders, but identify different patients. This study does not provide evidence that one criterion is better than another. A limited IGF-1 generation is not the major reason for a poor growth response in the first year of GH treatment in SGA and GHD children. Trial registration: Retrospectively registered.
Disciplines :
Pediatrics
Endocrinology, metabolism & nutrition
Author, co-author :
Straetemans, Saartje
Thomas, Muriel
Craen, Margarita
Rooman, Raoul
De Schepper, Jean
Parent, Anne-Simone ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
LEBRETHON, Marie-Christine ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Centre de l'obésité de l'enfant - adolescent
Language :
English
Title :
Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria.
Publication date :
October 2018
Journal title :
International Journal of Pediatric Endocrinology
ISSN :
1687-9848
eISSN :
1687-9856
Publisher :
BioMed Central (BMC), London, United Kingdom
Volume :
2018
Pages :
9
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Epub 2018 Oct 22
Available on ORBi :
since 17 December 2018

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