Reference : Cytomine: towards an open and collaborative software platform for digital pathology b...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Engineering, computing & technology : Computer science
http://hdl.handle.net/2268/230136
Cytomine: towards an open and collaborative software platform for digital pathology bridged to molecular investigations
English
Rubens, Ulysse mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Hoyoux, Renaud mailto [> >]
Vanosmael, Laurent [> >]
Ouras, Mehdy mailto [> >]
Tasset, Maxime mailto [> >]
Hamilton, Christopher mailto [> >]
Longuespée, Rémi mailto [University of Heidelberg > Institute of Pathology > > >]
Marée, Raphaël mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
6-Dec-2018
Proteomics. Clinical Applications
Wiley
Proteomics in Pathology
e1800057
Yes (verified by ORBi)
18628346
18628354
Germany
[en] bioinformatics
[en] PURPOSE: Digital histology is being increasingly used in research and clinical applications. In parallel new tissue imaging methods (e.g. imaging mass spectrometry) are currently regarded as very promising approaches for better molecular diagnosis in pathology. However, these new data sources are still often underexploited because of the lack of collaborative software to share and correlate information for multimodal analysis. EXPERIMENTAL DESIGN: We followed the open science paradigm to develop new features in our web-based Cytomine software to support next-generation digital pathology bridged to molecular investigations. RESULTS: Our new open-source developments allow to explore whole-slide classical histology with MALDI imaging and to support preprocessing for biomarker discovery using laser microdissection-based microproteomics. CONCLUSIONS AND CLINICAL RELEVANCE: Our updated version of Cytomine is the first open and web-based tool to enable sharing data from classical histology, molecular imaging and cell counting for proteomics preprocessing. It holds good promise to fulfill imminent needs in molecular histopathology. This article is protected by copyright. All rights reserved.
Fonds Européen de Développement Régional - FEDER ; Région wallonne : Direction générale des Technologies, de la Recherche et de l'Energie - DGTRE
http://hdl.handle.net/2268/230136
10.1002/prca.201800057
This article is protected by copyright. All rights reserved. http://www.interscience.wiley.com/

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