Article (Scientific journals)
Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).
Giebel, Sebastian; Marks, David I.; Boissel, Nicolas et al.
2019In Bone Marrow Transplantation, 54, p. 798-809
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Abstract :
[en] Allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission is a standard of care for adult patients with Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) and high risk of relapse. However, the stratification systems vary among study groups. Inadequate response at the level of minimal residual disease is the most commonly accepted factor indicating the need for alloHSCT. In this consensus paper on behalf of the European Working Group for Adult Acute Lymphoblastic Leukemia and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, we summarize available evidence and reflect current clinical practice in major European study groups regarding both indications for HSCT and particular aspects of the procedure including the choice of donor, source of stem cells and conditioning. Finally, we propose recommendations for daily clinical practice as well as for planning of prospective trials.
Disciplines :
Hematology
Author, co-author :
Giebel, Sebastian
Marks, David I.
Boissel, Nicolas
Baron, Frédéric  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Chiaretti, Sabina
Ciceri, Fabio
Cornelissen, Jan J.
Doubek, Michael
Esteve, Jordi
Fielding, Adele
Foa, Robin
Gorin, Norbert-Claude
Gokbuget, Nicola
Hallbook, Helene
Hoelzer, Dieter
Paravichnikova, Elena
Ribera, Josep-Maria
Savani, Bipin
Rijneveld, Anita W.
Schmid, Christoph
Wartiovaara-Kautto, Ulla
Mohty, Mohamad
Nagler, Arnon
Dombret, Herve
More authors (14 more) Less
Language :
English
Title :
Hematopoietic stem cell transplantation for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia in first remission: a position statement of the European Working Group for Adult Acute Lymphoblastic Leukemia (EWALL) and the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT).
Publication date :
2019
Journal title :
Bone Marrow Transplantation
ISSN :
0268-3369
eISSN :
1476-5365
Publisher :
Nature Publishing Group, United Kingdom
Volume :
54
Pages :
798-809
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 December 2018

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