What we need to know about lipid-associated injury in case of renal ischemia/reperfusion.

[en] Renal segmental metabolism is reflected by the complex distribution of the main energy pathways along the nephron, with fatty acid oxidation preferentially used in the cortex area. Ischemia/reperfusion injury (IRI) is due to the restriction of renal blood flow, rapidly leading to a metabolic switch towards anaerobic conditions. Subsequent unbalance between energy demand and oxygen/nutrient delivery compromises kidney cell functions, resulting to a complex inflammatory cascade including the production of reactive oxygen species (ROS). Renal IRI especially involves lipid accumulation. Lipid peroxidation is one of the major events of ROS-associated tissue injury. Here, we briefly review the current knowledge of renal cell lipid metabolism in normal and ischemic conditions. Next, we focus on renal lipid-associated injury, with emphasis on its mechanisms and consequences during the course of IRI. Finally, we discuss preclinical observations aiming at preventing and/or attenuating lipid-associated IRI.

Disciplines :

Urology & nephrology

Author, co-author :

ERPICUM, Pauline ; Département de médecine interne > Service de néphrologie

Rowart, Pascal ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie

Defraigne, Jean-Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique

Krzesinski, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie

Jouret, François ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie

Language :

English

Title :

What we need to know about lipid-associated injury in case of renal ischemia/reperfusion.

Publication date :

2018

Journal title :

American Journal of Physiology. Renal Physiology

ISSN :

1931-857X

eISSN :

1522-1466

Publisher :

American Physiological Society, Bethesda, United States - Maryland

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 November 2018

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