Reference : Decrease in SV2A expression in the hippocampus involves changes in cognition and anxi...
Scientific congresses and symposiums : Poster
Human health sciences : Laboratory medicine & medical technology
Human health sciences : Radiology, nuclear medicine & imaging
Decrease in SV2A expression in the hippocampus involves changes in cognition and anxiety-like features.
Serrano Navacerrada, Maria Elisa [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Bartholomé, Odile [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Van Den Ackerveken, Priscilla [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Rogister, Bernard [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie générales, et biochimie humaine >]
Tirelli, Ezio [Université de Liège - ULiège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér. >]
Plenevaux, Alain mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
11th FENS Forum of Neuroscience
from 07 July 2018 to 11 July 2018
Federation of European Neuroscience Societies
[en] SV2A ; knockout mice ; behaviour
[en] The Synaptic Vesicle Protein 2A (SV2A) is a transmembrane protein whose link with the epilepsy has been reported in multiples articles. However, the behavioral consequences of the decrease in its expression remain still unclear. The purpose of our research is to better understand the role of this protein through the evaluation of cKO (Grik4 +/-, SV2A lox/lox) mice of both sexes, which present a specific decrease in the hippocampus. After a first evaluation of the SV2A levels in the hippocampus with the in vitro [18F]UCB-H autoradiography, differences in brain metabolism were assessed with [18F]FDG in mPET and ex vivo autoradiography. Finally, the phenotype of cKO mice was analyzed with a behavioral test battery. Our results showed a strong reduction of SV2A expression in the whole hippocampus of cKO mice, with regard to the WT mice, not accompanied by statistically significant differences in brain metabolism between groups, either in vivo or ex vivo. No statistically significant differences were found in spontaneous locomotor activity or fear-linked memory. However, cKO males showed significant more anxiety than WT (less percent of entries in open arms) and females presented spatial memory deficits measured in the Barnes Maze (less time spend in quadrant during the test). These results could explain the comorbidity between anxiety, memory impairment and epilepsy present both in animal models and in humans, suggesting an important role of SV2A in the symptomatology of other neurodegenerative diseases, such as the Alzheimer disease, or in anxiety-related pathologies.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students

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