Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Balthazart, Jacques; Choleris, E.; Remage-Healey, L.

doi:10.1016/j.yhbeh.2018.01.002

Article (Scientific journals)

Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Balthazart, Jacques; Choleris, E.; Remage-Healey, L.

2018 • In Hormones and Behavior, 99, p. 1-8

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/229232

DOI
10.1016/j.yhbeh.2018.01.002

PubMed
29305886

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Keywords :

Aromatase; Behavioral neuroendocrinology; Genomic effects of steroids; History of endocrinology; Neurosteroids; Review

Abstract :

[en] This brief commentary reviews key steps in the history of steroid endocrinology that have resulted in important conceptual shifts. Our understanding of the “Fast Effects of Steroids” now reflect substantial progress, including the major concept that steroids act rapidly on a variety of physiological and behavioral responses, via mechanisms that are too fast to be fully accounted for by classical receptor-dependent regulation of gene transcription. Several so-called ‘non-classical’ mechanisms have been identified and include binding to membrane receptors and regulating non genomic signaling cascades. We survey the discovery of steroids, the initial characterization of their intracellular receptors, key progress in the understanding of the genomic effects of steroids and then the progressive discovery of the rapid non-classical and membrane-initiated actions of steroids. Foundational discoveries about brain steroid synthesis in neural processes and terminals has converged with emerging evidence for the rapid actions of steroids on brain and behavior. Had the rapid effects of steroids in the central nervous system been discovered first, these molecules would likely now be considered as a class of neurotransmitter. © 2018 Elsevier Inc.

Disciplines :

Animal psychology, ethology & psychobiology
Zoology
Neurosciences & behavior

Author, co-author :

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Choleris, E.; Department of Psychology and Neuroscience Program, University of Guelph, Guelph, Ontario, Canada

Remage-Healey, L.; Center for Neuroendocrine Studies, University of Massachusetts Amherst, Amherst, MA, United States

Language :

English

Title :

Steroids and the brain: 50 years of research, conceptual shifts and the ascent of non-classical and membrane-initiated actions

Publication date :

2018

Journal title :

Hormones and Behavior

ISSN :

0018-506X

eISSN :

1095-6867

Publisher :

Academic Press Inc.

Volume :

Pages :

1-8

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

RO1 NS082179; RO1 MH50388; NSERC 400212

Funders :

NIH - National Institutes of Health [US-MD] [US-MD]
NSERC - Natural Sciences and Engineering Research Council [CA]

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