Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida

[en] Menaquinone (vitamin K2) shuttles electrons between membrane-bound respiratory complexes under microaerophilic conditions. In photosynthetic eukaryotes and cyanobacteria, phylloquinone (vitamin K1) participates in photosystem I function. Here we elucidate the evolutionary history of vitamin K metabolism in algae and plants. We show that Chlamydiales intracellular pathogens made major genetic contributions to the synthesis of the naphthoyl ring core and the isoprenoid side-chain of these quinones. Production of the core in extremophilic red algae is under control of a menaquinone (Men) gene cluster consisting of 7 genes that putatively originated via lateral gene transfer (LGT) from a chlamydial donor to the plastid genome. In other green and red algae, functionally related nuclear genes also originated via LGT from a non-cyanobacterial, albeit unidentified source. In addition, we show that 3–4 of the 9 required steps for synthesis of the isoprenoid side chains are under control of genes of chlamydial origin. These results are discussed in the light of the hypoxic response experienced by the cyanobacterial endosymbiont when it gained access to the eukaryotic cytosol. © 2018, The Author(s).

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Cenci, U.; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France

Qiu, H.; Department of Ecology, Evolution & Natural Resources, Rutgers University, New Brunswick, NJ 08901, United States

Pillonel, T.; Center for Research on Intracellular Bacteria (CRIB), Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, 1011, Switzerland

Cardol, Pierre ; Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues

Remacle, Claire ; Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues

Colleoni, C.; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France

Kadouche, D.; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France

Chabi, M.; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France

Greub, G.; Center for Research on Intracellular Bacteria (CRIB), Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, 1011, Switzerland

Bhattacharya, D.; Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, United States

Ball, S. G.; Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France

Language :

English

Title :

Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida

Publication date :

2018

Journal title :

Scientific Reports

eISSN :

2045-2322

Publisher :

Nature Publishing Group

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 08 November 2018

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