Reference : Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/229178
Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida
English
Cenci, U. [Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France]
Qiu, H. [Department of Ecology, Evolution & Natural Resources, Rutgers University, New Brunswick, NJ 08901, United States]
Pillonel, T. [Center for Research on Intracellular Bacteria (CRIB), Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, 1011, Switzerland]
Cardol, Pierre mailto [Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues >]
Remacle, Claire mailto [Université de Liège - ULiège > Département des sciences de la vie > Génétique et physiologie des microalgues >]
Colleoni, C. [Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France]
Kadouche, D. [Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France]
Chabi, M. [Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France]
Greub, G. [Center for Research on Intracellular Bacteria (CRIB), Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, 1011, Switzerland]
Bhattacharya, D. [Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ 08901, United States]
Ball, S. G. [Unité de Glycobiologie Structurale et Fonctionnelle, UMR 8576 CNRS-USTL, Université des Sciences et Technologies de Lille, Bâtiment C9, Cité Scientifique, Villeneuve d’Ascq Cedex, 59655, France]
2018
Scientific Reports
Nature Publishing Group
8
1
Yes (verified by ORBi)
International
2045-2322
[en] Menaquinone (vitamin K2) shuttles electrons between membrane-bound respiratory complexes under microaerophilic conditions. In photosynthetic eukaryotes and cyanobacteria, phylloquinone (vitamin K1) participates in photosystem I function. Here we elucidate the evolutionary history of vitamin K metabolism in algae and plants. We show that Chlamydiales intracellular pathogens made major genetic contributions to the synthesis of the naphthoyl ring core and the isoprenoid side-chain of these quinones. Production of the core in extremophilic red algae is under control of a menaquinone (Men) gene cluster consisting of 7 genes that putatively originated via lateral gene transfer (LGT) from a chlamydial donor to the plastid genome. In other green and red algae, functionally related nuclear genes also originated via LGT from a non-cyanobacterial, albeit unidentified source. In addition, we show that 3–4 of the 9 required steps for synthesis of the isoprenoid side chains are under control of genes of chlamydial origin. These results are discussed in the light of the hypoxic response experienced by the cyanobacterial endosymbiont when it gained access to the eukaryotic cytosol. © 2018, The Author(s).
Researchers ; Professionals ; Students ; General public ; Others
http://hdl.handle.net/2268/229178
10.1038/s41598-018-33663-w

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