Predicting Disease Progression and Mortality in Aortic Stenosis: A Systematic Review of Imaging Biomarkers and Meta-Analysis.

Nchimi Longang, Alain; Dibato, John E.; DAVIN, Laurent; SCHOYSMAN, Laurent; Oury, Cécile; Lancellotti, Patrizio

doi:10.3389/fcvm.2018.00112

Article (Scientific journals)

Predicting Disease Progression and Mortality in Aortic Stenosis: A Systematic Review of Imaging Biomarkers and Meta-Analysis.

Nchimi Longang, Alain; Dibato, John E.; DAVIN, Laurent et al.

2018 • In Frontiers in Cardiovascular Medicine, 5, p. 112

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/228945

DOI
10.3389/fcvm.2018.00112

PubMed
30186838

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

fcvm-05-00112.pdf

Publisher postprint (861 kB)

Download

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

aortic stenosis; calcification; imaging biomarker; meta-analysis; myocardial fibrosis; remodeling

Abstract :

[en] Background: Detecting among patients with aortic stenosis (AS) those who are likely to rapidly progress, yet potentially benefiting from prophylactic aortic valve replacement, is needed for improved patient care. The objective of this study was to evaluate the role of imaging biomarkers in predicting the progression to clinical symptoms and death in patients with AS. Methods: We searched the Pubmed and the International Clinical Trials Registry Platform databases for studies including patients with AS, and investigating imaging techniques, published in any language until Jan 1, 2018. Eligible sets of data include effect of imaging biomarkers relative to: (1) Overall mortality, (2) Cardiac mortality, and (3) Overall events (Symptom onset and Major Adverse Cardiovascular Events). Meta-analysis was used to examine associations between the imaging biomarkers and outcomes of AS using Random Effect models. Results: Eight studies and 1,639 patients were included after systematic review. Four studies investigated aortic valve calcification (AVC) whereas the remaining investigated biomarkers provided by cardiac magnetic resonance (CMR). Four articles investigated the presence of midwall fibrosis on late-gadolinium enhancement imaging, three reported its extent (LGE%) and two, the myocardial extracellular volume (ECV). By decreasing strength of association, there were significant associations between cardiac mortality and LGE% [Relative Risk (RR) = 1.05, 95% Confidence Interval (CI) 1.01-1.10]; overall mortality and AVC (RR = 1.19, 95%CI: 1.05-1.36); overall events and ECV (RR = 1.68, 95%CI: 1.17-2.41); cardiac mortality and midwall fibrosis (RR = 2.88, 95%CI: 1.12-7.39). Conclusion: AVC and myocardial fibrosis imaging biomarkers predict the outcomes in AS, and help understanding AS pathophysiology and setting therapeutic targets.

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Nchimi Longang, Alain

Dibato, John E.

DAVIN, Laurent

SCHOYSMAN, Laurent

Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

Lancellotti, Patrizio ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation

Language :

English

Title :

Predicting Disease Progression and Mortality in Aortic Stenosis: A Systematic Review of Imaging Biomarkers and Meta-Analysis.

Publication date :

2018

Journal title :

Frontiers in Cardiovascular Medicine

eISSN :

2297-055X

Publisher :

Frontiers Research Foundation, Lausanne, Switzerland

Volume :

Pages :

112

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 29 October 2018

Statistics

Number of views

123 (10 by ULiège)

Number of downloads

114 (9 by ULiège)

More statistics

Scopus citations^®

Scopus citations^®
without self-citations

OpenCitations

OpenAlex citations

Bibliography

Nkomo, V.T., Gardin, J.M., Skelton, T.N., Gottdiener, J.S., Scott, C.G., Enriquez-Sarano, M., Burden of valvular heart diseases: a population-based study (2006) Lancet, 368, pp. 1005-1011. , 16980116
Hein, S., Arnon, E., Kostin, S., Schönburg, M., Elsässer, A., Polyakova, V., Progression from compensated hypertrophy to failure in the pressure-overloaded human: heart structural deterioration and compensatory mechanisms (2003) Circulation, 107, pp. 984-991. , 12600911
Lancellotti, P., Nchimi, A., Coronary microvascular reserve and outcome in aortic stenosis: pathophysiological significance vs. clinical relevance (2017) Eur Heart J, 38, pp. 1230-1232. , 28087603
Chin, C.W.L., Pawade, T.A., Newby, D.E., Dweck, M.R., Risk stratification in patients with aortic stenosis using novel imaging approaches (2015) Circ Cardiovasc Imaging, , 26198161, (,) 8:e003421
Nishimura, R.A., Otto, C.M., Bonow, R.O., Carabello, B.A., Erwin, J.P., Guyton, R.A., 2014 AHA/ACC guideline for the management of patients with valvular heart disease: executive summary :a report of the american college of cardiology/american heart association task force on practice guidelines (2014) Circulation, 129, pp. 2440-2492. , 24589852
Baumgartner, H., Hung, J., Bermejo, J., Chambers, J.B., Edvardsen, T., Goldstein, S., Recommendations on the echocardiographic assessment of aortic valve stenosis: a focused update from the European association of cardiovascular imaging and the American Society of Echocardiography (2017) Eur Hear J Cardiovasc Imaging, 18, pp. 254-275
Lancellotti, P., Magne, J., Donal, E., Davin, L., O'Connor, K., Rosca, M., Clinical outcome in asymptomatic severe aortic stenosis (2012) J Am Coll Cardiol, 59, pp. 235-243. , 22240128
Dulgheru, R., Pibarot, P., Sengupta, P.P., Piérard, L.A., Rosenhek, R., Magne, J., Multimodality imaging strategies for the assessment of aortic stenosis: viewpoint of the heart valve clinic international database (HAVEC) group (2016) Circ Cardiovasc Imaging, 9, p. e004352. , 26863917
Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement (2015) Syst Rev J, 4, pp. 1-9. , 25554246
Higgins, J.P.T., Altman, D.G., Gotzsche, P.C., Juni, P., Moher, D., Oxman, A.D., The Cochrane Collaboration's tool for assessing risk of bias in randomised trials (2011) BMJ, 343, p. d5928. , 22008217
Cooper, H.M., Hedges, L.V., Research synthesis as a scientific enterprise (1994) Handb Res Synth Meta-analysis, pp. 3-17. , https://books.google.de/books?id=p-aFAwAAQBAJ, In:, (,) p. Available online at
Paule, R.C., Mandel, J., Consensus values and weighting factors (1982) J Res Natl Bur Stand, 87, pp. 377-385
Borenstein, M., Hedges, L., Higgins, J., Rothstein, H., (2009) Introduction to Meta-Analysis, , Chichester, Wiley & Sons, 26061376
Blaha, M.J., Budoff, M.J., Rivera, J.J., Khan, A.N., Santos, R.D., Shaw, L.J., Relation of aortic valve calcium detected by cardiac computed tomography to all-cause mortality (2010) Am J Cardiol, 106, pp. 1787-1791. , 21055710
Nguyen, V., Cimadevilla, C., Estellat, C., Codogno, I., Huart, V., Benessiano, J., Haemodynamic and anatomic progression of aortic stenosis (2015) Heart, 101, pp. 943-947. , 25655063
Cueff, C., Serfaty, J.M., Cimadevilla, C., Laissy, J.P., Himbert, D., Tubach, F., Measurement of aortic valve calcification using multislice computed tomography:correlation with haemodynamic severity of aortic stenosis and clinical implication for patients with low ejection fraction (2011) Heart, 97, pp. 721-726. , 20720250
Cowell, S.J., Newby, D.E., Burton, J., White, A., Northridge, D.B., Boon, N.A., Aortic valve calcification on computed tomography predicts the severity of aortic stenosis (2003) Clin Radiol, 58, pp. 712-716. , 12943644
Dweck, M.R., Jenkins, W.S.A., Vesey, A.T., Pringle, M.A.H., Chin, C.W.L., Malley, T.S., 18F-Sodium Fluoride uptake is a marker of active calcification and disease progression in patients with aortic stenosis (2014) Circ Cardiovasc Imaging, 7, pp. 371-378. , 24508669
Chin, C.W.L., Shah, A.S.V., McAllister, D.A., Cowell, S.J., Alam, S., Langrish, J.P., High-sensitivity troponin i concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis (2014) Eur Heart J, 35, pp. 2312-2321. , 24829362
Shah, A.S.V., Chin, C.W.L., Vassiliou, V., Cowell, S.J., Doris, M., Kwok, T.C., Left ventricular hypertrophy with strain and aortic stenosis (2014) Circulation, 130, pp. 1607-1616. , 25170097
Chin, C.W.L., Messika-Zeitoun, D., Shah, A.S.V., Lefevre, G., Bailleul, S., Yeung, E.N.W., A clinical risk score of myocardial fibrosis predicts adverse outcomes in aortic stenosis (2016) Eur Heart J, 37, pp. 713-723. , 26491110
Vassiliou, V.S., Perperoglou, A., Raphael, C.E., Joshi, S., Malley, T., Everett, R., Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis (2017) J Am Coll Cardiol, 69, pp. 1755-1756. , 28359524
Dweck, M.R., Joshi, S., Murigu, T., Alpendurada, F., Jabbour, A., Melina, G., Midwall fibrosis is an independent predictor of mortality in patients with aortic stenosis (2011) J Am Coll Cardiol, 58, pp. 1271-1279. , 21903062
Azevedo, C.F., Nigri, M., Higuchi, M.L., Pomerantzeff, P.M., Spina, G.S., Sampaio, R.O., Prognostic significance of myocardial fibrosis quantification by histopathology and magnetic resonance imaging in patients with severe aortic valve disease (2010) J Am Coll Cardiol, 56, pp. 278-287. , 20633819
Weidemann, F., Herrmann, S., Störk, S., Niemann, M., Frantz, S., Lange, V., Impact of myocardial fibrosis in patients with symptomatic severe aortic stenosis (2009) Circulation, 120, pp. 577-584. , 19652094
Barone-Rochette, G., Piérard, S., De Meester De Ravenstein, C., Seldrum, S., Melchior, J., Maes, F., Pouleur, A.C., Prognostic significance of LGE by CMR in aortic stenosis patients undergoing valve replacement (2014) J Am Coll Cardiol, 64, pp. 144-154. , 25011718
Musa, T., Al Uddin, A., Swoboda, P.P., Garg, P., Fairbairn, T.A., Dobson, L.E., Myocardial strain and symptom severity in severe aortic stenosis: insights from cardiovascular magnetic resonance (2017) Quant Imaging Med Surg, 7, pp. 38-47. , 28275558
Dahl, J.S., Videbaek, L., Poulsen, M.K., Rudbaek, T.R., Pellikka, P.A., Moller, J.E., Global strain in severe aortic valve stenosis: relation to clinical outcome after aortic valve replacement (2012) Circ Cardiovasc Imaging, 5, pp. 613-620. , 22869821
Aksoy, O., Cam, A., Agarwal, S., Ige, M., Yousefzai, R., Singh, D., Significance of aortic valve calcification in patients with low-gradient low-flow aortic stenosis (2014) Clin Cardiol, 37, pp. 26-31. , 24122890
Feuchtner, G., Müller, S., Grander, W., Alber, H., Bartel, T., Friedrich, G., Aortic valve calcification as quantified with multislice computed tomography predicts short-term clinical outcome in patients with asymptomatic aortic stenosis (2006) J Heart Valve Dis, 15, pp. 494-498. , 16901041
Utsunomiya, H., Yamamoto, H., Kitagawa, T., Kunita, E., Urabe, Y., Tsushima, H., Incremental prognostic value of cardiac computed tomography angiography in asymptomatic aortic stenosis: significance of aortic valve calcium score (2013) Int J Cardiol, 168, pp. 5205-5211. , 23978365
Lee, H., Park, J.B., Yoon, Y.E., Park, E.A., Kim, H.K., Lee, W., Noncontrast Myocardial T1 mapping by cardiac magnetic resonance predicts outcome in patients with aortic stenosis (2017) JACC Cardiovasc Imaging, 11, pp. 974-983. , 29153562
Messika-Zeitoun, D., Aubry, M.-C., Detaint, D., Bielak, L.F., Peyser, P.A., Sheedy, P.F., Evaluation and clinical implications of aortic valve calcification measured by electron-beam computed tomography (2004) Circulation, 110, pp. 356-362. , 15249504
Clavel, M.-A., Pibarot, P., Messika-Zeitoun, D., Capoulade, R., Malouf, J., Aggarval, S., Impact of aortic valve calcification, as measured by MDCT, on survival in patients with aortic stenosis results of an international registry study (2014) J Am Coll Cardiol, 64, pp. 1202-1213. , 25236511
Chin, C.W.L., Everett, R.J., Kwiecinski, J., Vesey, A.T., Yeung, E., Esson, G., Myocardial Fibrosis and Cardiac Decompensation in Aortic Stenosis (2017) JACC Cardiovasc Imaging, 10, pp. 1320-1333. , 28017384
Singh, A., Greenwood, J.P., Berry, C., Dawson, D.K., Hogrefe, K., Kelly, D.J., Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the Prognostic importance of MIcrovascular dysfunction in aortic stenosis (PRIMIDAS) study (2017) Eur Heart J, 38, pp. 1222-1229
Pellikka, P.A., Sarano, M.E., Nishimura, R.A., Malouf, J.F., Bailey, K.R., Scott, C.G., Outcome of 622 adults with asymptomatic, hemodynamically significant aortic stenosis during prolonged follow-up (2005) Circulation, 111, pp. 3290-3295. , 15956131
Agatston, A.S., Janowitz, W.R., Hildner, F.J., Zusmer, N.R., Viamonte, M., Detrano, R., Quantification of coronary artery calcium using ultrafast computed tomography (1990) J Am Coll Cardiol, 15, pp. 827-832. , 2407762
Flett, A.S., Sado, D.M., Quarta, G., Mirabel, M., Pellerin, D., Herrey, A.S., Diffuse myocardial fibrosis in severe aortic stenosis: an equilibrium contrast cardiovascular magnetic resonance study (2012) Eur Heart J Cardiovasc Imaging, 13, pp. 819-826. , 22634740
Flett, A.S., Hayward, M.P., Ashworth, M.T., Hansen, M.S., Taylor, A.M., Elliott, P.M., Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans (2010) Circulation, 122, pp. 138-144. , 20585010
Nazarian, S., Is ventricular arrhythmia a possible mediator of the association between aortic stenosis-related midwall fibrosis and mortality? (2011) J Am Coll Cardiol, 58, pp. 1280-1282. , 21903063
Flett, A.S., Hasleton, J., Cook, C., Hausenloy, D., Quarta, G., Ariti, C., Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance (2011) JACC Cardiovasc Imaging, 4, pp. 150-156. , 21329899
Hamilton-Craig, C.R., Strudwick, M.W., Galloway, G.J., T1 Mapping for Myocardial fibrosis by cardiac magnetic resonance relaxometry - a comprehensive technical review (2016) Front Cardiovasc Med, 3, pp. 1-11. , 28361053
Dweck, M.R., Khaw, H.J., Sng, G.K.Z., Luo, E.L.C., Baird, A., Williams, M.C., Aortic stenosis, atherosclerosis, and skeletal bone: Is there a common link with calcification and inflammation? (2013) Eur Heart J, 34, pp. 1567-1574. , 23391586
Marincheva-Savcheva, G., Subramanian, S., Qadir, S., Figueroa, A., Truong, Q., Vijayakumar, J., Imaging of the aortic valve using fluorodeoxyglucose positron emission tomography: increased valvular fluorodeoxyglucose uptake in aortic stenosis (2011) J Am Coll Cardiol, 57, pp. 2507-2515. , 21679852
Dweck, M.R., Jones, C., Joshi, N.V., Fletcher, A.M., Richardson, H., White, A., Assessment of valvular calcification and inflammation by positron emission tomography in patients with aortic stenosis (2012) Circulation, 125, pp. 76-86. , 22090163
Thanassoulis, G., Campbell, C.Y., Owens, D.S., Smith, J.G., Smith, A.V., Peloso, G.M., Genetic associations with valvular calcification and aortic stenosis (2013) N Engl J Med, 368, pp. 503-512. , 23388002
Aggarwal, S.R., Clavel, M.-A., Messika-Zeitoun, D., Cueff, C., Malouf, J., Araoz, P.A., Sex differences in aortic valve calcification measured by multidetector computed tomography in aortic stenosis (2013) Circ Cardiovasc Imaging, 6, pp. 40-47. , 23233744
Abramowitz, Y., Jilaihawi, H., Pibarot, P., Chakravarty, T., Kashif, M., Kazuno, Y., Severe aortic stenosis with low aortic valve calcification: characteristics and outcome following transcatheter aortic valve implantation (2017) Eur Heart J Cardiovasc Imaging, 18, pp. 639-647. , 28369223
Mahmod, M., Piechnik, S.K., Levelt, E., Ferreira, V.M., Francis, J.M., Lewis, A., Adenosine stress native T1 mapping in severe aortic stenosis: evidence for a role of the intravascular compartment on myocardial T1 values (2014) J Cardiovasc Magn Reson, 16, p. 92. , 25410203
Mancio, J., Fontes-Carvalho, R., Oliveira, M., Caeiro, D., Braga, P., Bettencourt, N., Coronary artery disease and symptomatic severe aortic valve stenosis: clinical outcomes after transcatheter aortic valve implantation (2015) Front Cardiovasc Med, 2, p. 18. , 26664890
Kellman, P., Bandettini, W.P., Mancini, C., Hammer-Hansen, S., Hansen, M.S., Arai, A.E., Characterization of myocardial T1-mapping bias caused by intramyocardial fat in inversion recovery and saturation recovery techniques (2015) J Cardiovasc Magn Reson, , 25958014, (,) 17:33
Mewton, N., Liu, C.Y., Croisille, P., Bluemke, D., Lima, J., Assessment of Myocardial fibrosis with cardiac magnetic resonance (2011) J Am Coll Cardiol, 57, pp. 891-903
Treibel, T.A., Kozor, R., Schofield, R., Benedetti, G., Fontana, M., Bhuva, A.N., (2018) Reverse myocardial remodeling following valve replacement in patients with aortic stenosis, 71, pp. 860-871. , 29471937
van Ooij, P., Markl, M., Collins, J.D., Carr, J.C., Rigsby, C., Bonow, R.O., Aortic valve stenosis alters expression of regional aortic wall shear stress: New insights from a 4-dimensional flow magnetic resonance imaging study of 571 subjects (2017) J Am Heart Assoc, 6, p. e005959. , 28903936
Oury, C., Servais, L., Bouznad, N., Hego, A., Nchimi, A., Lancellotti, P., MicroRNAs in valvular heart diseases: potential role as markers and actors of valvular and cardiac remodeling (2016) Int J Mol Sci, 17, p. 1120. , 27420053
Lancellotti, P., Dulgheru, R., Magne, J., Henri, C., Servais, L., Bouznad, N., Elevated plasma soluble sT2 is associated with heart failure symptoms and outcome in aortic stenosis (2015) PLoS ONE, , 26390433, (,) 10:e0138940
Jung, C., Lichtenauer, M., Figulla, H.-R., Wernly, B., Goebel, B., Foerster, M., Microparticles in patients undergoing transcatheter aortic valve implantation (TAVI) (2017) Heart Vessels, 32, pp. 458-466. , 27488119
Wernly, B., Lichtenauer, M., Jirak, P., Eder, S., Reiter, C., Kammler, J., Soluble ST2 predicts 1-year outcome in patients undergoing transcatheter aortic valve implantation (2017) Eur J Clin Invest, 47, pp. 149-157. , 28036122