Article (Scientific journals)
The Recognition of Hypothalamo-Neurohypophysial Functions by Developing T Cells
Robert, F. R.; Martens, Henri; Cormann, N. et al.
1992In Developmental Immunology, 2 (2), p. 131-40
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Abstract :
[en] Neuropeptide signals and specific neuropeptide receptors have been described in the thymus supporting the concept of a close dialogue between the neuroendocrine and the immune systems at the level of early T-cell differentiation. In this paper, we review recent data about neurohypophysial (NHP)-related peptides detected in the thymus from different species. We suggest that we are dealing in fact with other member(s) of the NHP hormone family, which seems to exert its activity locally through a novel model of cell-to-cell signaling, that of cryptocrine communication. This model involves exchange of signals between thymic epithelial cells and developing thymocytes. The NHP-related peptides have been shown to trigger thymocyte proliferation and could induce immune tolerance of this highly conserved neuroendocrine family.
Disciplines :
Immunology & infectious disease
Endocrinology, metabolism & nutrition
Author, co-author :
Robert, F. R.
Martens, Henri ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Embryologie
Cormann, N.
Benhida, A.
Schoenen, Jean  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
Language :
English
Title :
The Recognition of Hypothalamo-Neurohypophysial Functions by Developing T Cells
Publication date :
1992
Journal title :
Developmental Immunology
ISSN :
1044-6672
Publisher :
Hindawi Publishing Corporation
Volume :
2
Issue :
2
Pages :
131-40
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 September 2009

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