[en] Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from the psychiatric disorders. We also identified significant sharing between disorders and a number of brain phenotypes, including cognitive measures. Further, we conducted simulations to explore how statistical power, diagnostic misclassification, and phenotypic heterogeneity affect genetic correlations. These results highlight the importance of common genetic variation as a risk factor for brain disorders and the value of heritability-based methods in understanding their etiology.
Disciplines :
Genetics & genetic processes
Author, co-author :
Anttila, Verneri
Bulik-Sullivan, Brendan
Finucane, Hilary K.
Walters, Raymond K.
Bras, Jose
Duncan, Laramie
Escott-Price, Valentina
Falcone, Guido J.
Gormley, Padhraig
Malik, Rainer
Patsopoulos, Nikolaos A.
Ripke, Stephan
Wei, Zhi
Yu, Dongmei
Lee, Phil H.
Turley, Patrick
Grenier-Boley, Benjamin
Chouraki, Vincent
Kamatani, Yoichiro
Berr, Claudine
Letenneur, Luc
Hannequin, Didier
Amouyel, Philippe
Boland, Anne
Deleuze, Jean-Francois
Duron, Emmanuelle
Vardarajan, Badri N.
Reitz, Christiane
Goate, Alison M.
Huentelman, Matthew J.
Kamboh, M. Ilyas
Larson, Eric B.
Rogaeva, Ekaterina
St George-Hyslop, Peter
Hakonarson, Hakon
Kukull, Walter A.
Farrer, Lindsay A.
Barnes, Lisa L.
Beach, Thomas G.
Demirci, F. Yesim
Head, Elizabeth
Hulette, Christine M.
Jicha, Gregory A.
Kauwe, John S. K.
Kaye, Jeffrey A.
Leverenz, James B.
Levey, Allan I.
Lieberman, Andrew P.
Pankratz, Vernon S.
Poon, Wayne W.
Quinn, Joseph F.
Saykin, Andrew J.
Schneider, Lon S.
Smith, Amanda G.
Sonnen, Joshua A.
Stern, Robert A.
Van Deerlin, Vivianna M.
Van Eldik, Linda J.
Harold, Denise
Russo, Giancarlo
Rubinsztein, David C.
Bayer, Anthony
Tsolaki, Magda
Proitsi, Petra
Fox, Nick C.
Hampel, Harald
Owen, Michael J.
Mead, Simon
Passmore, Peter
Morgan, Kevin
Nothen, Markus M.
Rossor, Martin
Lupton, Michelle K.
Hoffmann, Per
Kornhuber, Johannes
Lawlor, Brian
McQuillin, Andrew
Al-Chalabi, Ammar
Bis, Joshua C.
Ruiz, Agustin
Boada, Merce
Seshadri, Sudha
Beiser, Alexa
Rice, Kenneth
van der Lee, Sven J.
De Jager, Philip L.
Geschwind, Daniel H.
Riemenschneider, Matthias
Riedel-Heller, Steffi
Rotter, Jerome I.
Ransmayr, Gerhard
Hyman, Bradley T.
Cruchaga, Carlos
Alegret, Montserrat
Winsvold, Bendik
Palta, Priit
Farh, Kai-How
Cuenca-Leon, Ester
Furlotte, Nicholas
Kurth, Tobias
Ligthart, Lannie
Terwindt, Gisela M.
Freilinger, Tobias
Ran, Caroline
Gordon, Scott D.
Borck, Guntram
Adams, Hieab H. H.
Lehtimaki, Terho
Wedenoja, Juho
Buring, Julie E.
Schurks, Markus
Hrafnsdottir, Maria
Hottenga, Jouke-Jan
Penninx, Brenda
Artto, Ville
Kaunisto, Mari
Vepsalainen, Salli
Martin, Nicholas G.
Montgomery, Grant W.
Kurki, Mitja I.
Hamalainen, Eija
Huang, Hailiang
Huang, Jie
Sandor, Cynthia
Webber, Caleb
Muller-Myhsok, Bertram
Schreiber, Stefan
Salomaa, Veikko
Loehrer, Elizabeth
Gobel, Hartmut
Macaya, Alfons
Pozo-Rosich, Patricia
Hansen, Thomas
Werge, Thomas
Kaprio, Jaakko
Metspalu, Andres
Kubisch, Christian
Ferrari, Michel D.
Belin, Andrea C.
van den Maagdenberg, Arn M. J. M.
Zwart, John-Anker
Boomsma, Dorret
Eriksson, Nicholas
Olesen, Jes
Chasman, Daniel I.
Nyholt, Dale R.
Avbersek, Andreja
Baum, Larry
Berkovic, Samuel
Bradfield, Jonathan
Buono, Russell
Catarino, Claudia B.
Cossette, Patrick
De Jonghe, Peter
Depondt, Chantal
Dlugos, Dennis
Ferraro, Thomas N.
French, Jacqueline
Hjalgrim, Helle
Jamnadas-Khoda, Jennifer
Kalviainen, Reetta
Kunz, Wolfram S.
Lerche, Holger
Leu, Costin
Lindhout, Dick
Lo, Warren
Lowenstein, Daniel
McCormack, Mark
Moller, Rikke S.
Molloy, Anne
Ng, Ping-Wing
Oliver, Karen
Privitera, Michael
Radtke, Rodney
Ruppert, Ann-Kathrin
Sander, Thomas
Schachter, Steven
Schankin, Christoph
Scheffer, Ingrid
Schoch, Susanne
Sisodiya, Sanjay M.
Smith, Philip
Sperling, Michael
Striano, Pasquale
Surges, Rainer
Thomas, G. Neil
Visscher, Frank
Whelan, Christopher D.
Zara, Federico
Heinzen, Erin L.
Marson, Anthony
Becker, Felicitas
Stroink, Hans
Zimprich, Fritz
Gasser, Thomas
Gibbs, Raphael
Heutink, Peter
Martinez, Maria
Morris, Huw R.
Sharma, Manu
Ryten, Mina
Mok, Kin Y.
Pulit, Sara
Bevan, Steve
Holliday, Elizabeth
Attia, John
Battey, Thomas
Boncoraglio, Giorgio
Thijs, Vincent
Chen, Wei-Min
Mitchell, Braxton
Rothwell, Peter
Sharma, Pankaj
Sudlow, Cathie
Vicente, Astrid
Markus, Hugh
Kourkoulis, Christina
Pera, Joana
Raffeld, Miriam
Silliman, Scott
Boraska Perica, Vesna
Thornton, Laura M.
Huckins, Laura M.
William Rayner, N.
Lewis, Cathryn M.
Gratacos, Monica
Rybakowski, Filip
Keski-Rahkonen, Anna
Raevuori, Anu
Hudson, James I.
Reichborn-Kjennerud, Ted
Monteleone, Palmiero
Karwautz, Andreas
Mannik, Katrin
Baker, Jessica H.
O'Toole, Julie K.
Trace, Sara E.
Davis, Oliver S. P.
Helder, Sietske G.
Ehrlich, Stefan
Herpertz-Dahlmann, Beate
Danner, Unna N.
van Elburg, Annemarie A.
Clementi, Maurizio
Forzan, Monica
DOCAMPO MARTINEZ, Elisa ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de rhumatologie
Analysis of shared heritability in common disorders of the brain.
Publication date :
2018
Journal title :
Science
ISSN :
0036-8075
eISSN :
1095-9203
Publisher :
American Association for the Advancement of Science, Washington, United States - District of Columbia
Volume :
360
Issue :
6395
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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