Article (Scientific journals)
Serum creatinine: advantages and pitfalls
Bargnoux, Anne-Sophie; Kuster, Nils; CAVALIER, Etienne et al.
2018In Journal of Laboratory and Precision Medicine
 

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Keywords :
creatinine; imprecision; bias; biological variability
Abstract :
[en] Serum creatinine (sCr) is today the most commonly used marker to estimate glomerular filtration rate (GFR). However, measuring and interpreting creatinine is not so simple. Some physiological reasons, particularly its dependence on muscle mass makes sCr an imperfect biomarker of GFR. However, there are also analytical reasons that could be further improved. The implementation of ID-MS traceable creatinine assays (enzymatic and compensated Jaffe) improved estimation of GFR by reducing bias. Enzymatic methods which are more precise and less susceptible to interfere with non-creatinine chromogens than compensated Jaffe methods, provide more reliable estimations of GFR.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Bargnoux, Anne-Sophie
Kuster, Nils
CAVALIER, Etienne  ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de chimie clinique
Piéroni, Laurence
Souweine, Jean-Sébastien
DELANAYE, Pierre  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Cristol, Jean-Pierre
Language :
English
Title :
Serum creatinine: advantages and pitfalls
Publication date :
2018
Journal title :
Journal of Laboratory and Precision Medicine
eISSN :
2519-9005
Publisher :
AME Publishing Company, Hong Kong, China
Available on ORBi :
since 09 October 2018

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