Reference : Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblast...
Scientific journals : Article
Human health sciences : Pediatrics
Human health sciences : Laboratory medicine & medical technology
http://hdl.handle.net/2268/228406
Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study
English
Delvin, E. [Sainte-Justine UHC Research Centre, Canada, Department of Biochemistry and Molecular Medicine, Université de Montréal, Canada]
Alos, N. [Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada]
Rauch, F. [Shriners Hospital for Children, Canada, McGill University Health Centre Research Institute, McGill University, Montreal, Canada]
Marcil, V. [Sainte-Justine UHC Research Centre, Canada, Department of Nutrition, Université de Montréal, Canada]
Morel, S. [Sainte-Justine UHC Research Centre, Canada]
Boisvert, M. [Sainte-Justine UHC Research Centre, Canada]
Lecours, M.-A. [Sainte-Justine UHC Research Centre, Canada]
Laverdière, C. [Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada]
Sinnett, D. [Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada]
Krajinovic, M. [Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada]
Dubois, Jacques mailto [Université de Liège - ULiège > > Relations académiques et scientifiques (Philo et lettres) >]
Drouin, S. [Sainte-Justine UHC Research Centre, Canada]
Lefebvre, G. [Department of Mathematics, Université du Québec à Montréal, Canada]
Samoilenko, M. [Department of Mathematics, Université du Québec à Montréal, Canada]
Nyalendo, C. [Sainte-Justine UHC Research Centre, Canada, Department of Clinical Biochemistry, Sainte-Justine UHC, Université de Montréal, Montréal, Canada]
Cavalier, Etienne mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Levy, Etienne mailto [Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies >]
In press
Clinical Nutrition
Churchill Livingstone
Yes (verified by ORBi)
International
02615614
15321983
[en] Acute lymphoblastic leukemia ; Bone formation ; Bone resorption ; CTX ; P1NP
[en] Background: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. Objective: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. Results: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44–2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5–97.5%iles) intake is 600 IU/d (21.2–1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 – <50 nM). Serum 24,25(OH)2D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. Conclusion: The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
CCS, CCSRI, Canadian Cancer Society Research Institute; POGO, Pediatric Oncology Group of Ontario; CRS, Cancer Research Society; ICR, Institute for Chemical Research, Kyoto University; CIHR, Canadian Institutes of Health Research; TCF 118694, POGO, Partnership for Observation of the Global Oceans; OICR, Ontario Institute for Cancer Research; SickKids, Hospital for Sick Children; ICR, Institute of Cancer Research; CIHR, Canadian Institutes of Health Research; CRS, Cancer Research Society
http://hdl.handle.net/2268/228406
10.1016/j.clnu.2018.02.006

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