Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study

Delvin, E.; Alos, N.; Rauch, F.; Marcil, V.; Morel, S.; Boisvert, M.; Lecours, M.-A.; Laverdière, C.; Sinnett, D.; Krajinovic, M.; Dubois, J.; Drouin, S.; Lefebvre, G.; Samoilenko, M.; Nyalendo, C.; Cavalier, Etienne; Levy, Etienne

doi:10.1016/j.clnu.2018.02.006

Article (Scientific journals)

Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study

Delvin, E.; Alos, N.; Rauch, F. et al.

2019 • In Clinical Nutrition

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/228406

DOI
10.1016/j.clnu.2018.02.006

PubMed
29503055

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Keywords :

Acute lymphoblastic leukemia; Bone formation; Bone resorption; CTX; P1NP

Abstract :

[en] Background: The remarkable progress in the treatment of childhood acute lymphoblastic leukemia (cALL) has led to a survival rate reaching 90%. This success story is unfortunately linked to increased risk of impaired skeletal mass accumulation during childhood and adolescence, predisposing the patients to osteoporosis and pathological fractures at adulthood. Objective: This study aims at characterizing the vitamin D status and bone health biomarkers in a well-characterized cohort of cALL survivors. Results: Food frequency questionnaires reveal that (i) the total vitamin D intake varies greatly (44–2132 IU/d), (ii) only 16.8% of the participants consume vitamin D supplements, and (iii) 74% of survivors' intakes are below the Recommended Daily Intakes (400 IU/d). For the 42 participants taking vitamin D supplements, the median (2.5–97.5%iles) intake is 600 IU/d (21.2–1972 IU/d). Sixteen participants are vitamin D deficient (<30 nM) and 66 insufficient (≥30 – <50 nM). Serum 24,25(OH)2D3 concentrations are directly related to those of 25OHD3, and those of 3-epi-25OHD3 below the Lower Limit of Quantification in most samples. The participants' serum concentrations of cross-linked C-telopeptide of type-I collagen and intact amino-terminal pro-peptide of type-I collagen decrease steadily with age, leveling at adulthood, and are at all times higher in males. Conclusion: The present study shows that the prevalence of vitamin D insufficiency or deficiency is not greater in cALL survivors compared to the general Canadian population despite low vitamin D food and supplement intakes. Furthermore, there seem to be no overt imbalance in the gender- and age-adjusted serum bone turnover marker concentrations. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

Disciplines :

Laboratory medicine & medical technology
Pediatrics

Author, co-author :

Delvin, E.; Sainte-Justine UHC Research Centre, Canada, Department of Biochemistry and Molecular Medicine, Université de Montréal, Canada

Alos, N.; Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada

Rauch, F.; Shriners Hospital for Children, Canada, McGill University Health Centre Research Institute, McGill University, Montreal, Canada

Marcil, V.; Sainte-Justine UHC Research Centre, Canada, Department of Nutrition, Université de Montréal, Canada

Morel, S.; Sainte-Justine UHC Research Centre, Canada

Boisvert, M.; Sainte-Justine UHC Research Centre, Canada

Lecours, M.-A.; Sainte-Justine UHC Research Centre, Canada

Laverdière, C.; Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada

Sinnett, D.; Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada

Krajinovic, M.; Sainte-Justine UHC Research Centre, Canada, Department of Pediatrics, Université de Montréal, Canada

More authors (7 more)

Language :

English

Title :

Vitamin D nutritional status and bone turnover markers in childhood acute lymphoblastic leukemia survivors: A PETALE study

Publication date :

2019

Journal title :

Clinical Nutrition

ISSN :

0261-5614

eISSN :

1532-1983

Publisher :

Churchill Livingstone

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

CIHR - Canadian Institutes of Health Research [CA]

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