Reference : Inclusion of 17β-estradiol into liposome prevent the activation of membrane initiated...
Scientific congresses and symposiums : Poster
Human health sciences : Multidisciplinary, general & others
http://hdl.handle.net/2268/227864
Inclusion of 17β-estradiol into liposome prevent the activation of membrane initiated signaling of ERalpha
English
Gallez, Anne mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Palazzo, Claudio []
Evrard, Brigitte mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Noël, Agnès mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Piel, Géraldine mailto [Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments >]
Pequeux, Christel mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
2018
No
International
EMBO Workshop/ Nuclear receptors and biological networks
du 11 au 15 septembre 2018
Susanne Mandrup , Jason Carroll , Donald McDonnell et Iannis Talianidis
Kolymbari
Crete
[en] 147 Beta Estradiol ; MISS Pathways ; Liposomes
[en] Estrogens are implicated in many physiological and pathological processes thanks to their interaction with estrogen receptors (ERs). The estrogen receptor alpha (ERα) controls reproduction, normal mammary gland development and breast cancer progression. The activation of ERα by estrogens, especially by 17β-estradiol (E2), leads to two major pathways: (1) the genomic effects associated to the transcriptional activity of the ERα and (2) the MISS (Membrane Initiated Steroid Signaling) effects related to the induction of fast signaling pathways occurring when ERα is anchored to the plasma membrane.
Liposome are small non-toxic and biodegradable vectors widely studied for treatment of pathologies, like multiple sclerosis, Parkinson and Alzheimer disease and cancer. The encapsulation of several types of molecules (proteins, DNA and steroids), the protection of the activity and the improvement of the pharmacokinetic properties of these compounds represent the main advantages of liposome’s use. However, the impact of the encapsulation on molecular mechanisms is not yet established. As a proof of concept, we evaluate the impact of E2 inclusion into liposome (named POPC E2) in vitro and in vivo on ERα signaling pathway activation.
http://hdl.handle.net/2268/227864

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