[en] Delayed graft function (DGF) is defined as the need for dialysis within 7 days following kidney transplantation (KTx). DGF is associated with increased costs, higher risk for acute rejection and decreased long-term graft function. Renal ischaemia/reperfusion (I/R) injury plays a major role in DGF occurrence. Single nucleotide polymorphisms (SNPs) in certain genes may aggravate kidney susceptibility to I/R injury, thereby worsening post-transplant outcomes. The present article proposes an extensive review of the literature about the putative impact of donor or recipient SNPs on DGF occurrence in kidney transplant recipients (KTRs). Among 30 relevant PubMed reports, 16 articles identified an association between 18 SNPs and DGF. These polymorphisms concern 14 different well-known genes and one not-yet-identified gene located on chromosome 18. They have been categorized into five groups according to the role of the corresponding proteins in I/R cascade: (i) oxidative stress, (ii) telomere shortening, (iii) chemokines, (iv) T-cell homeostasis and (v) metabolism of anti-inflammatory molecules. The remaining 14 studies failed to demonstrate any association between the studied SNPs and the occurrence of DGF. A better understanding of the genetic susceptibility to renal I/R injury may help prevent DGF and improve clinical outcomes in KTRs.
Disciplines :
Urology & nephrology
Author, co-author :
HUART, Justine ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de néphrologie
Krzesinski, Jean-Marie ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Jouret, François ; Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Language :
English
Title :
Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature.
Mallon DH, Summers DM, Bradley JA et al. Defining delayed graft function after renal transplantation: simplest is best. Transplantation 2013; 96: 885-889
Domanski L, Bobrek-Lesiakowska K, Kłoda K et al. Lack of association of the rs2476601 PTPN22 gene polymorphism with transplanted kidney function. Ann Transplant 2011; 16: 63-68
Rege A, Irish B, Castleberry A et al. Trends in usage and outcomes for expanded criteria donor kidney transplantation in the United States characterized by kidney donor profile index. Cureus 2016; 8: e887
Lafuente O, Sánchez-Sobrino B, Pérez M et al. Midterm results of renal transplantation from controlled cardiac death donors are similar to those from brain death donors. Transplant Proc 2016; 48: 2862-2866
Erpicum P, Detry O, Weekers L et al. Mesenchymal stromal cell therapy in conditions of renal ischaemia/reperfusion. Nephrol Dial Transplant 2014; 29: 1487-1493
Niemann CU, Feiner J, Swain S et al. Therapeutic hypothermia in deceased organ donors and kidney-graft function. N Engl J Med 2015; 373: 405-414
Kłoda K, Domanski L, Pawlik A et al. Effect of the ICAM1 and VCAM1 gene polymorphisms on delayed graft function and acute kidney allograft rejection. Ann Transplant 2010 15: 15-20
Siedlecki A, Irish W, Brennan DC. Delayed graft function in the kidney transplant. Am J Transplant 2011; 11: 2279-2296
Rowart P, Erpicum P, Detry O et al. Mesenchymal stromal cell therapy in ischemia/reperfusion injury. J Immunol Res 2015; 2015: 602597
Grigoryev DN, Cheranova DI, Heruth DP et al. Meta-analysis of molecular response of kidney to ischemia reperfusion injury for the identification of new candidate genes. BMC Nephrol 2013; 14: 231
Wilflingseder J, Sunzenauer J, Toronyi E et al. Molecular pathogenesis of post-transplant acute kidney injury: assessment of whole-genome mRNA and miRNA profiles. PLoS One 2014; 9: e104164
Krüger B, Schröppel B, Murphy BT. Genetic polymorphisms and the fate of the transplanted organ. Transplant Rev 2008; 22: 131-140
St. Peter SD, Imber CJ, Jones DC et al. Genetic determinants of delayed graft function after kidney transplantation. Transplantation 2002; 74: 809-813
Singh R, Manchanda PK, Kesarwani P et al. Influence of genetic polymorphisms in GSTM1, GSTM3, GSTT1 and GSTP1 on allograft outcome in renal transplant recipients. Clin Transplant 2009; 23: 490-498
Dutkiewicz G, Domanski L, BINCZAK-KULETA A et al. The association of -262C/T polymorphism in the catalase gene and delayed graft function of kidney allografts. Nephrology (Carlton) 2010; 15: 587-591
Mandegary A, Rahmanian-Koshkaki S, Mohammadifar MA et al. Investigation of association between donors' and recipients' NADPH oxidase p22(phox) C242T polymorphism and acute rejection, delayed graft function and blood pressure in renal allograft recipients. Transpl Immunol 2015; 32: 46-50
Kłoda K, Domanski L, Kwiatkowska E et al. hTERT, BICD1 and chromosome 18 polymorphisms associated with telomere length affect kidney allograft function after transplantation. Kidney Blood Press Res 2015; 40: 111-120
Kłoda K, Domanski L, Kwiatkowska E et al. BICD1 and chromosome 18 polymorphisms associated with recipients' telomere length affect kidney allograft function after transplantation. Transplant Proc 2016; 48: 1451-1455
Kłoda K, Mierzecki A, Domanski L et al. Joint assessment of donor and recipient hTERT gene polymorphism provides additional information for early kidney transplantation outcomes. Med Sci Monit 2017; 23: 1812-1818
Manchanda PK, Bid HK, Kumar A et al. Genetic association of interleukin-1b and receptor antagonist (IL-1Ra) gene polymorphism with allograft function in renal transplant patients. Transpl Immunol 2006; 15: 289-296
Mandegary A, Azmandian J, Soleymani S et al. Effect of donor tumor necrosis factor-alpha and interleukin-10 genotypes on delayed graft function and acute rejection in kidney transplantation. Iran J Kidney Dis 2013; 7: 135-141
Dabrowska-Zamojcin E, Dziedziejko V, Safranow K et al. Association between the CX3CR1 gene V249I polymorphism and delayed kidney allograft function. Transpl Immunol 2015; 32: 172-174
Domanski L, Bobrek-Lesiakowska K, Kłoda K et al. The impact of rs231775 (þ49AG) CTLA4 gene polymorphism on transplanted kidney function. Ann Transplant 2012; 17: 29-35
Misra MK, Kapoor R, Pandey SK et al. Association of CTLA-4 gene polymorphism with end-stage renal disease and renal allograft outcome. J Interferon Cytokine Res 2014; 34: 148-161
Krüger B, Banas MC, Walberer A et al. A comprehensive genotype-phenotype interaction of different Toll-like receptor variations in a renal transplant cohort. Clin Sci 2010; 119: 535-544
Gervasini G, Garcia M, Macias RM et al. CYP2C8*3 polymorphism and donor age are associated with allograft dysfunction in kidney transplant recipients treated with calcineurin inhibitors. J Clin Pharmacol 2013; 53: 427-434
Dabrowska-Zamojcin E, Czerewaty M, Malinowski D et al. Ficolin-2 gene rs7851696 polymorphism is associated with delayed graft function and acute rejection in kidney allograft recipients. Arch Immunol Ther Exp (Warsz) 2018; 66: 65-72
Dutkiewicz G, Domanski L, Binczak-Kuleta A et al. The association between eNOS intron 4 VNTR polymorphism and delayed graft function of kidney allografts. Clin Transplant 2010; 24: E130-E136
Dutkiewicz G, Domanski L, Binczak-Kuleta A et al. Lack of association of polymorphisms 239þ34A/C in the SOD1 gene and 47C/T in the SOD2 gene with delayed graft function and acute and chronic rejection of kidney allografts. Transplant Proc 2009; 41: 3701-3703
McDaniel DO, Barber WH, Nguyan C et al. Combined analysis of cytokine genotype polymorphism and the level of expression with allograft function in African-American renal transplant patients. Transpl Immunol 2003; 11: 107-119
Israni AK, Li N, Cizman BB et al. Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation. Am J Kidney Dis 2008; 52: 331-339
Mange KC, Prak EL, Kamoun M et al. Duffy antigen receptor and genetic susceptibility of African Americans to acute rejection and delayed function. Kidney Int 2004; 66: 1187-1192
Hoffmann TW, Halimi JM, Büchler M et al. Impact of a polymorphism in the IL-12p40 gene on the outcome of kidney transplantation. Transplant Proc 2009; 41: 654-656
Azmandian J, Mandegary A, Saber A et al. Chemokine receptor 2-V64I and chemokine receptor 5-D32 polymorphisms and clinical risk factors of delayed graft function and acute rejection in kidney transplantation. Iran J Kidney Dis 2012; 6: 56-62
Kwiatkowska E, Domanski L, Kłoda K et al. IL2-IL21 gene cluster polymorphism is not associated with allograft function after kidney transplantation. Int Urol Nephrol 2014; 46: 2415-2420
Pawlus J, Sierocka A, Tejchman K et al. The impact of interleukin 12B (1188A>C), interleukin 16 (-295T>C), and interleukin 18 (607C>A, 137G>C) gene polymorphisms on long-term renal transplant function and recipient outcomes. Transplant Proc 2014; 46: 2079-2082
Dabrowska-Zamojcin E, Dziedziejko V, Safranow K et al. STAT4 gene polymorphism in patients after renal allograft transplantation. Cent J Immunol 2016; 41: 255-259
Damman J, Kok JL, Snieder H et al. Lectin complement pathway gene profile of the donor and recipient does not influence graft outcome after kidney transplantation. Mol Immunol 2012; 50: 1-8
Michielsen LA, van Zuilen AD, Muskens IS et al. Complement polymorphisms in kidney transplantation: critical in graft rejection? Am J Transplant 2017; 17: 2000-2007
Zukowski M, Kotfis K, Biernawska J et al. Association of the rs10918594 of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphisms with the graft function after kidney transplantation. Ann Transplant 16: 72-76
Belda-Antolí M, Padrón-Sanz C, Cejalvo-Lapeña D et al. Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel. Surgery 2017; 162: 577-585
Johnson KJ, Weinberg JM. Postischemic renal injury due to oxygen radicals. Curr Opin Nephrol Hypertens 1993; 2: 625-635
Zhou J, Zhang YH, Song HZ et al. 5d, a novel analogue of 3-n-butylphthalide, decreases NADPH oxidase activity through the positive regulation of CK2 after ischemia/reperfusion injury. Oncotarget 2016; 7: 39444-39457
Chkhotua A, Abendroth D, Schelzig H. Renal ischemia/reperfusion and its influence on telomere length and expression of cell cycle regulatory genes. Georgian Med News 2006; 130: 22-26
Blanco JR, Jarrin I, Martinez A et al. Shorter telomere length predicts poorer immunological recovery in virologically suppressed HIV-1-infected patients treated with combined antiretroviral therapy. JAIDS J Acquir Immune Defic Syndr 2015; 68: 21-29
Daemen MA, van de Ven MW, Heineman E et al. Involvement of endogenous interleukin-10 and tumor necrosis factor-alpha in renal ischemia-reperfusion injury. Transplantation 1999; 67: 792-800
Cornell LD, Smith RN, Colvin RB. Kidney transplantation: mechanisms of rejection and acceptance. Annu Rev Pathol Mech Dis 2008; 3: 189-220
Liu YZ, Wang C, Wang Q et al. Role of fractalkine/CX3CR1 signaling pathway in the recovery of neurological function after early ischemic stroke in a rat model. Life Sci 2017; 184: 87-94
Alegre ML, Leemans J, Le Moine A et al. The multiple facets of toll-like receptors in transplantation biology. Transplantation 2008; 86: 1-9
Krüger B, Krick S, Dhillon N et al. Donor toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation. Proc Natl Acad Sci USA 2009; 106: 3390-3395
Node K, Huo Y, Ruan X et al. Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids. Science 1999; 285: 1276-1279
Alkayed NJ, Goyagi T, Joh HD et al. Neuroprotection and P450 2C11 upregulation after experimental transient ischemic attack. Stroke 2002; 33: 1677-1684
Zeldin DC, Moomaw CR, Jesse N et al. Biochemical characterization of the human liver cytochrome P450 arachidonic acid epoxygenase pathway. Arch Biochem Biophys 1996; 330: 87-96
Hummelshoj T, Munthe-Fog L, Madsen HO et al. Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. Hum Mol Genet 2005; 14: 1651-1658
Melk A, Ramassar V, Helms LM et al. Telomere shortening in kidneys with age. J Am Soc Nephrol 2000; 11: 444-453
Kłoda K, Domanski L, Mierzecki A. Telomere length assessment for prediction of organ transplantation outcome. Future or failure: a review of the literature. Med Sci Monit 2017; 23: 158-162
Berger SP, Roos A, Mallat MJK et al. Association between mannose-binding lectin levels and graft survival in kidney transplantation. Am J Transplant 2005; 5: 1361-1366
Damman J, Daha MR, Leuvenink HG et al. Association of complement C3 gene variants with renal transplant outcome of deceased cardiac dead donor kidneys. Am J Transplant 2012; 12: 660-668
Pihlstrøm HK, Mjøen G, Mucha S et al. Single nucleotide polymorphisms and long-term clinical outcome in renal transplant patients: a validation study. Am J Transplant 2017; 17: 528-533
Moore J, Tan K, Cockwell P et al. Predicting early renal allograft function using clinical variables. Nephrol Dial Transplant 2007; 22: 2669-2677
Palanisamy AP, Schiltz CE, Pilch NA et al. Cardiovascular risk factors contribute to disparities in graft outcomes in African American renal transplant recipients: a retrospective analysis. Blood Press 2015; 24: 14-22
Willicombe M, Rizzello A, Goodall D et al. Risk factors and outcomes of delayed graft function in renal transplant recipients receiving a steroid sparing immunosuppression protocol. World J Transplant 2017; 7: 34
Irish WD, McCollum DA, Tesi RJ et al. Nomogram for predicting the likelihood of delayed graft function in adult cadav-eric renal transplant recipients. J Am Soc Nephrol 2003; 14: 2967-2974
