Reference : Genetic susceptibility to delayed graft function following kidney transplantation: a ...
Scientific journals : Article
Human health sciences : Urology & nephrology
http://hdl.handle.net/2268/227807
Genetic susceptibility to delayed graft function following kidney transplantation: a systematic review of the literature.
English
Huart, Justine mailto [> >]
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > Département des sciences cliniques > Néphrologie >]
Jouret, François mailto [Université de Liège - ULiège > Département des sciences cliniques > Néphrologie >]
2018
Clinical Kidney Journal
11
4
586-596
Yes (verified by ORBi)
International
2048-8505
2048-8513
England
[en] delayed graft function ; ischaemia/reperfusion ; kidney transplantation ; polymorphisms ; renal allograft
[en] Delayed graft function (DGF) is defined as the need for dialysis within 7 days following kidney transplantation (KTx). DGF is associated with increased costs, higher risk for acute rejection and decreased long-term graft function. Renal ischaemia/reperfusion (I/R) injury plays a major role in DGF occurrence. Single nucleotide polymorphisms (SNPs) in certain genes may aggravate kidney susceptibility to I/R injury, thereby worsening post-transplant outcomes. The present article proposes an extensive review of the literature about the putative impact of donor or recipient SNPs on DGF occurrence in kidney transplant recipients (KTRs). Among 30 relevant PubMed reports, 16 articles identified an association between 18 SNPs and DGF. These polymorphisms concern 14 different well-known genes and one not-yet-identified gene located on chromosome 18. They have been categorized into five groups according to the role of the corresponding proteins in I/R cascade: (i) oxidative stress, (ii) telomere shortening, (iii) chemokines, (iv) T-cell homeostasis and (v) metabolism of anti-inflammatory molecules. The remaining 14 studies failed to demonstrate any association between the studied SNPs and the occurrence of DGF. A better understanding of the genetic susceptibility to renal I/R injury may help prevent DGF and improve clinical outcomes in KTRs.
http://hdl.handle.net/2268/227807
10.1093/ckj/sfy020

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