Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse.

[en] Macrophages are highly plastic innate immune cells that adopt an important diversity of phenotypes in response to environmental cues. Helminth infections induce strong type 2 cell-mediated immune responses, characterized among other things by production of high levels of interleukin- (IL-) 4 and IL-13. Alternative activation of macrophages by IL-4 in vitro was described as an opposite phenotype of classically activated macrophages, but the in vivo reality is much more complex. Their exact activation state as well as the role of these cells and associated molecules in type 2 immune responses remains to be fully understood. We can take advantage of a variety of helminth models available, each of which have their own feature including life cycle, site of infection, or pathological mechanisms influencing macrophage biology. Here, we reviewed the recent advances from the laboratory mouse about macrophage origin, polarization, activation, and effector functions during parasitic helminth infection.

Disciplines :

Immunology & infectious disease

Author, co-author :

Rolot, Marion ; Université de Liège - ULiège > Immunologie et vaccinologie

Dewals, Benjamin G ; Université de Liège - ULiège > Immunologie et vaccinologie

Language :

English

Title :

Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse.

Publication date :

2018

Journal title :

Journal of Immunology Research

ISSN :

2314-8861

eISSN :

2314-7156

Publisher :

Hindawi, Egypt

Volume :

2018

Pages :

2790627

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 September 2018

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