Reference : Helminth-induced IL-4 expands bystander memory CD8(+) T cells for early control of vi...
Scientific journals : Article
Human health sciences : Immunology & infectious disease
http://hdl.handle.net/2268/227555
Helminth-induced IL-4 expands bystander memory CD8(+) T cells for early control of viral infection.
English
Rolot, Marion mailto [Université de Liège - ULiège > > Immunologie et vaccinologie >]
Dougall, Annette M. [> >]
Chetty, Alisha [> >]
Javaux, Justine mailto [Université de Liège - ULiège > > Immunologie et vaccinologie >]
Chen, Ting mailto [Université de Liège - ULiège > > Immunologie et vaccinologie >]
Xiao, Xue [> >]
Machiels, Bénédicte mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
Selkirk, Murray E. [> >]
Maizels, Rick M. [> >]
Hokke, Cornelis [> >]
Denis, Olivier [> >]
Brombacher, Frank [> >]
Vanderplasschen, Alain mailto [Université de Liège - ULiège > > Immunologie et vaccinologie >]
Gillet, Laurent mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire >]
Horsnell, William G. C. [> >]
Dewals, Benjamin G mailto [Université de Liège - ULiège > > Immunologie et vaccinologie >]
2018
Nature Communications
9
1
4516
Yes (verified by ORBi)
International
20411723
England
[en] Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8(+) T cells (TVM) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the TVM compartment. Here, we show that helminths expand CD44(hi)CD62L(hi)CXCR3(hi)CD49d(lo) TVM cells through direct IL-4 signaling in CD8(+) T cells. Importantly, helminth-mediated conditioning of TVM cells provided enhanced control of acute respiratory infection with the murid gammaherpesvirus 4 (MuHV-4). This enhanced control of MuHV-4 infection could further be explained by an increase in antigen-specific CD8(+) T cell effector responses in the lung and was directly dependent on IL-4 signaling. These results demonstrate that IL-4 during helminth infection can non-specifically condition CD8(+) T cells, leading to a subsequently raised antigen-specific CD8(+) T cell activation that enhances control of viral infection.
http://hdl.handle.net/2268/227555
also: http://hdl.handle.net/2268/229061
10.1038/s41467-018-06978-5

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