Helminth-induced IL-4 expands bystander memory CD8(+) T cells for early control of viral infection.

[en] Infection with parasitic helminths can imprint the immune system to modulate bystander inflammatory processes. Bystander or virtual memory CD8(+) T cells (TVM) are non-conventional T cells displaying memory properties that can be generated through responsiveness to interleukin (IL)-4. However, it is not clear if helminth-induced type 2 immunity functionally affects the TVM compartment. Here, we show that helminths expand CD44(hi)CD62L(hi)CXCR3(hi)CD49d(lo) TVM cells through direct IL-4 signaling in CD8(+) T cells. Importantly, helminth-mediated conditioning of TVM cells provided enhanced control of acute respiratory infection with the murid gammaherpesvirus 4 (MuHV-4). This enhanced control of MuHV-4 infection could further be explained by an increase in antigen-specific CD8(+) T cell effector responses in the lung and was directly dependent on IL-4 signaling. These results demonstrate that IL-4 during helminth infection can non-specifically condition CD8(+) T cells, leading to a subsequently raised antigen-specific CD8(+) T cell activation that enhances control of viral infection.

Disciplines :

Immunology & infectious disease

Author, co-author :

Rolot, Marion ; Université de Liège - ULiège > Immunologie et vaccinologie

Dougall, Annette M.

Chetty, Alisha

Javaux, Justine ; Université de Liège - ULiège > Immunologie et vaccinologie

Chen, Ting ; Université de Liège - ULiège > Immunologie et vaccinologie

Xiao, Xue

Machiels, Bénédicte ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire

Selkirk, Murray E.

Maizels, Rick M.

Hokke, Cornelis

More authors (6 more)

Language :

English

Title :

Helminth-induced IL-4 expands bystander memory CD8(+) T cells for early control of viral infection.

Publication date :

2018

Journal title :

Nature Communications

eISSN :

2041-1723

Publisher :

Nature Publishing Group, United Kingdom

Volume :

Issue :

Pages :

4516

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 06 September 2018

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