Reference : Metallic nanoparticles: an interesting option for mass spectrometry imaging of small ...
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Chemistry
http://hdl.handle.net/2268/227303
Metallic nanoparticles: an interesting option for mass spectrometry imaging of small molecules in tissues
English
Verdin, Alexandre mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
Müller, Wendy mailto []
Bertrand, Virginie mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
Malherbe, Cédric mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique >]
Eppe, Gauthier mailto [Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique >]
De Pauw, Edwin mailto [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de spectrométrie de masse (L.S.M.) >]
5-Jul-2018
A0
No
No
International
Chemistry Department Day
5 juillet 2018
ULiège
Liège
Belgique
[en] Mass spectrometry ; molecular imaging ; nanoparticles ; surface-assisted laser desorption/ionisation ; biological tissues
[en] MALDI mass spectrometry imaging is a central technique for the visualisation and identification of a wide variety of molecules in biological samples, especially in tissues slides. However, organic matrices used for the desorption and ionisation of molecules suffers from major limitations, particularly for the analysis of small molecules due to interferences from the matrix in the low m/z range. In this preliminary study we compared the performances of 9-aminoacridine, a well known organic matrix used for small molecules anaylsis, and metallic nanoparticles to evaluate the information obtained from both method. Ionisation by nanoparticles is known as Surface-Assisted Laser Desorption Ionisation (SALDI). Metallic nanoparticles seem to be a promising substrate for MS analysis of small compounds in tissues and reveals information that are complementary to those obtained by MALDI.
Laboratoire de Chimie Analytique Inorganique (LCAi) ; Laboratoire de Spectrométrie de Masse (LSM)
ULiège
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/227303

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