Article (Scientific journals)
Implications of AMPK in the Formation of Epithelial Tight Junctions
Rowart, Pascal; Wu, Jingshing; Caplan, Michael J. et al.
2018In International Journal of Molecular Sciences
Peer Reviewed verified by ORBi
 

Files


Full Text
ijms-19-02040.pdf
Publisher postprint (1.06 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
AMPK; Tight Junctions; Epithelial Cells
Abstract :
[en] Tight junctions (TJ) play an essential role in the epithelial barrier. By definition, TJ are located at the demarcation between the apical and baso-lateral domains of the plasma membrane in epithelial cells. TJ fulfill two major roles: (i) TJ prevent the mixing of membrane components; and (ii) TJ regulate the selective paracellular permeability. Disruption of TJ is regarded as one of the earliest hallmarks of epithelial injury, leading to the loss of cell polarity and tissue disorganization. Many factors have been identified as modulators of TJ assembly/disassembly. More specifically, in addition to its role as an energy sensor, adenosine monophosphate-activated protein kinase (AMPK) participates in TJ regulation. AMPK is a ubiquitous serine/threonine kinase composed of a catalytic -subunit complexed with regulatory -and -subunits. AMPK activation promotes the early stages of epithelial TJ assembly. AMPK phosphorylates the adherens junction protein afadin and regulates its interaction with the TJ-associated protein zonula occludens (ZO)-1, thereby facilitating ZO-1 distribution to the plasma membrane. In the present review, we detail the signaling pathways up-and down-stream of AMPK activation at the time of Ca2+-induced TJ assembly.
Disciplines :
Urology & nephrology
Author, co-author :
Rowart, Pascal ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Wu, Jingshing
Caplan, Michael J.
Jouret, François  ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Language :
English
Title :
Implications of AMPK in the Formation of Epithelial Tight Junctions
Publication date :
13 July 2018
Journal title :
International Journal of Molecular Sciences
ISSN :
1661-6596
eISSN :
1422-0067
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 13 August 2018

Statistics


Number of views
69 (9 by ULiège)
Number of downloads
81 (4 by ULiège)

Scopus citations®
 
39
Scopus citations®
without self-citations
39
OpenCitations
 
37

Bibliography


Similar publications



Contact ORBi