Reference : Implications of AMPK in the Formation of Epithelial Tight Junctions
Scientific journals : Article
Human health sciences : Urology & nephrology
http://hdl.handle.net/2268/227035
Implications of AMPK in the Formation of Epithelial Tight Junctions
English
Rowart, Pascal mailto [Université de Liège - ULiège > Département des sciences cliniques > Néphrologie >]
Wu, Jingshing [> >]
Caplan, Michael J. mailto [> >]
Jouret, François mailto [Université de Liège - ULiège > Département des sciences cliniques > Néphrologie >]
13-Jul-2018
International Journal of Molecular Sciences
Multidisciplinary Digital Publishing Institute (MDPI)
Yes (verified by ORBi)
International
1422-0067
Switzerland
[en] AMPK ; Tight Junctions ; Epithelial Cells
[en] Tight junctions (TJ) play an essential role in the epithelial barrier. By definition, TJ are
located at the demarcation between the apical and baso-lateral domains of the plasma membrane
in epithelial cells. TJ fulfill two major roles: (i) TJ prevent the mixing of membrane components;
and (ii) TJ regulate the selective paracellular permeability. Disruption of TJ is regarded as one of the
earliest hallmarks of epithelial injury, leading to the loss of cell polarity and tissue disorganization.
Many factors have been identified as modulators of TJ assembly/disassembly. More specifically,
in addition to its role as an energy sensor, adenosine monophosphate-activated protein kinase (AMPK)
participates in TJ regulation. AMPK is a ubiquitous serine/threonine kinase composed of a catalytic
-subunit complexed with regulatory -and
-subunits. AMPK activation promotes the early stages
of epithelial TJ assembly. AMPK phosphorylates the adherens junction protein afadin and regulates
its interaction with the TJ-associated protein zonula occludens (ZO)-1, thereby facilitating ZO-1
distribution to the plasma membrane. In the present review, we detail the signaling pathways up-and down-stream of AMPK activation at the time of Ca2+-induced TJ assembly.
http://hdl.handle.net/2268/227035
10.3390/ijms19070040
http://www.mdpi.com/1422-0067/19/7/2040

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