Reference : Phosphate wasting disorders in adults
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/226850
Phosphate wasting disorders in adults
English
Marcucci, G [> >]
Masi, L [> >]
Ferrari, S [> >]
Haffner, D [> >]
Javaid, M.K. [> >]
Kamenicky, P [> >]
Reginster, Jean-Yves mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Rizzoli, R [> >]
Brandi, M.L. [> >]
2018
Osteoporosis International
Springer
29
2369-2387
Yes (verified by ORBi)
International
0937-941X
1433-2965
Germany
[en] FGF-23 ; Hypophosphatemia ; Osteomalacia ; phosphate wasting disorders ; rickets ; Treatment
[en] A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23
pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments.
http://hdl.handle.net/2268/226850
10.1007/s00198-018-4618-2

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