Article (Scientific journals)
Phosphate wasting disorders in adults
Marcucci, G; Masi, L; Ferrari, S et al.
2018In Osteoporosis International, 29, p. 2369-2387
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Keywords :
FGF-23; Hypophosphatemia; Osteomalacia; phosphate wasting disorders; rickets; Treatment
Abstract :
[en] A cause of hypophosphatemia is phosphate wasting disorders. Knowledge concerning mechanisms involved in phosphate wasting disorders has greatly increased in the last decade by the identification of phosphatonins, among them FGF-23. FGF-23 is a primarily bone derived factor decreasing renal tubular reabsorption of phosphate and the synthesis of calcitriol. Currently, pharmacological treatment of these disorders offers limited efficacy and is potentially associated to gastrointestinal, renal, and parathyroid complications; therefore, efforts have been directed toward newer pharmacological strategies that target the FGF-23 pathway. This review focuses on phosphate metabolism, its main regulators, and phosphate wasting disorders in adults, highlighting the main issues related to diagnosis and current and new potential treatments.
Disciplines :
General & internal medicine
Author, co-author :
Marcucci, G
Masi, L
Ferrari, S
Haffner, D
Javaid, M.K.
Kamenicky, P
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Rizzoli, R
Brandi, M.L.
Language :
English
Title :
Phosphate wasting disorders in adults
Publication date :
2018
Journal title :
Osteoporosis International
ISSN :
0937-941X
eISSN :
1433-2965
Publisher :
Springer, Germany
Volume :
29
Pages :
2369-2387
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 August 2018

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