[en] Background: High fructose intake causes hepatic insulin resistance
and increases postprandial blood glucose, lactate, triglyceride,
and uric acid concentrations. Uric acid may contribute to insulin
resistance and dyslipidemia in the general population. In
patients with hereditary fructose intolerance, fructose consumption
is associated with acute hypoglycemia, renal tubular acidosis, and
hyperuricemia.
Objective: We investigated whether asymptomatic carriers for
hereditary fructose intolerance (HFI) would have a higher sensitivity
to adverse effects of fructose than would the general population.
Design: Eight subjects heterozygous for HFI (hHFI; 4 men, 4
women) and 8 control subjects received a low-fructose diet for
7 d and on the eighth day ingested a test meal, calculated to
provide 25% of the basal energy requirement, containing 13C-labeled
fructose (0.35 g/kg), glucose (0.35 g/kg), protein (0.21 g/kg), and
lipid (0.22 g/kg). Glucose rate of appearance (GRa, calculated with
[6,6-2H2]glucose), fructose, net carbohydrate, and lipid oxidation,
and plasma triglyceride, uric acid, and lactate concentrations were
monitored over 6 h postprandially.
Results: Postprandial GRa, fructose, net carbohydrate, and lipid
oxidation, and plasma lactate and triglyceride concentrations were
not significantly different between the 2 groups. Postprandial plasma
uric acid increased by 7.2% compared with fasting values in hHFI
subjects (P < 0.01), but not in control subjects (−1.1%, ns).
Conclusions: Heterozygous carriers of hereditary fructose intolerance
had no significant alteration of postprandial fructose
metabolism compared with control subjects. They did, however,
show a postprandial increase in plasma uric acid concentration
that was not observed in control subjects in responses to ingestion
of a modest amount of fructose. This trial was registered at the
US Clinical Trials Registry as NCT02979106.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
DEBRAY, François-Guillaume ; Centre Hospitalier Universitaire de Liège - CHU > Unilab > Consultation Génétque
DAMJANOVIC, Katarina; Université de Lausanne > Faculté de Biologie
ROSSET, Robin; Université de Lausanne > Faculté de biologie
MITTAZ-CRETOL, Lauréane; Université de Lausanne > Genetic Medicine
ROUX, Clothilde; Université de Lausanne > Clinical Chemestry
BRAISSANT, Olivier; Université de Lausanne > Clinical Chemestry
BARBEY, Frédéric; Université de Lausanne > Genetic Medicine
BONAFE, Luisa; Université de Lausanne > Genetic Medicine
DE BANDT, Jean-Pascal; Université Paris Descartes > Faculté de pharmacie
TAPPY, Luc; Université de Lausanne > Physiologie
PAQUOT, Nicolas ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de diabétologie, nutrition, maladies métaboliques
TRAN, Christel; Université de Lausanne > Physiologie
Language :
English
Title :
Are heterozygous carriers for hereditary fructose intolerance predisposed to metabolic disturbances when exposed to fructose?
Publication date :
2018
Journal title :
American Journal of Clinical Nutrition
ISSN :
0002-9165
eISSN :
1938-3207
Publisher :
American Society for Clinical Nutrition, United States - Maryland
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