Reference : Female sexual behavior in mice is controlled by kisspeptin neurons.
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/226140
Female sexual behavior in mice is controlled by kisspeptin neurons.
English
Hellier, Vincent mailto [Université de Liège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
Brock, Olivier mailto [Université de Liège - ULiège > > > Doct. sc. (biol. orga. & écol. - Bologne)]
Candlish, Michael [> >]
Desroziers, Elodie mailto [> >]
Aoki, Mari [> >]
Mayer, Christian [> >]
Piet, Richard [> >]
Herbison, Allan [> >]
Colledge, William Henry [> >]
Prevot, Vincent [> >]
Boehm, Ulrich [> >]
Bakker, Julie mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la différenciation sexuelle du cerveau >]
2018
Nature Communications
9
1
400
Yes (verified by ORBi)
International
2041-1723
United Kingdom
[en] Animals ; Female ; Gonadotropin-Releasing Hormone/secretion ; Kisspeptins/genetics/metabolism ; Male ; Mating Preference, Animal ; Mice, Knockout ; Neurons/physiology ; Nitric Oxide/metabolism ; Nitric Oxide Synthase/metabolism ; Odorants ; Posture ; Sexual Behavior, Animal/physiology ; Ventromedial Hypothalamic Nucleus/physiology
[en] Sexual behavior is essential for the survival of many species. In female rodents, mate preference and copulatory behavior depend on pheromones and are synchronized with ovulation to ensure reproductive success. The neural circuits driving this orchestration in the brain have, however, remained elusive. Here, we demonstrate that neurons controlling ovulation in the mammalian brain are at the core of a branching neural circuit governing both mate preference and copulatory behavior. We show that male odors detected in the vomeronasal organ activate kisspeptin neurons in female mice. Classical kisspeptin/Kiss1R signaling subsequently triggers olfactory-driven mate preference. In contrast, copulatory behavior is elicited by kisspeptin neurons in a parallel circuit independent of Kiss1R involving nitric oxide signaling. Consistent with this, we find that kisspeptin neurons impinge onto nitric oxide-synthesizing neurons in the ventromedial hypothalamus. Our data establish kisspeptin neurons as a central regulatory hub orchestrating sexual behavior in the female mouse brain.
http://hdl.handle.net/2268/226140
10.1038/s41467-017-02797-2

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