Reference : Increased hippocampal volume in exercising mice: comparison of control conditions wit...
Scientific congresses and symposiums : Poster
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/225755
Increased hippocampal volume in exercising mice: comparison of control conditions with in vivo voxel based morphometry
English
Becker, Guillaume [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Lespine, Louis-Ferdinand [Université de Liège - ULiège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér. >]
Bahri, Mohamed Ali [Université de Liège - ULiège > > Aging & Memory >]
Bruneel, Jérôme []
Serrano Navacerrada, Maria Elisa [Université de Liège - ULiège > > Preclinical Imaging >]
Luxen, André [Université de Liège - ULiège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse >]
Tirelli, Ezio [Université de Liège - ULiège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér. >]
Plenevaux, Alain mailto [Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences) >]
Mar-2018
Yes
International
European Molecular Imaging Meeting - EMIM 2018
21 - 23 March 2018
European Society for Molecular Imaging
San Sebastian
Spain
[en] MRI ; physical exercise ; preclinical imaging ; wheel-running ; neuroplasticity ; hippocampus ; neurogenesis
[en] Introduction
Both human and animal studies have shown that physical exercise (primarily aerobic exercise) may have facilitating effects on brain plasticity and cognition. In rodents, improvements of various forms of learning and memory induced by wheel-running have been associated with numerous neuroplastic changes such as increased hippocampal neurogenesis. A few studies, using magnetic resonance imaging (MRI), consistently reported hippocampal volumetric increase relative to non-exercising mice. However, the control group is commonly limited either to a locked wheel or no wheel.
Methods
In the present study, we intended to test whether 6 weeks of voluntary wheel-running exercise during adulthood induced a detectable volumetric change in mice brain in comparison to non-exercised control mice housed either with a locked wheel or without such wheel.
54 C57Bl6 males were randomly assigned to one of the three groups and individually housed for 6 weeks before imaging session. MRI (Agilent 9.4T) acquisition consisted in 3D T2 volume sequence (voxel size: 0.21 mm isotropic) using a dedicated surface coil receiver. We used Dartel soware for the preprocessing of the data, and the Voxel Based Morphometry was done with SPM mouse toolbox (F test, threshold p < .001 uncor). A small volume correction was applied to limit the analysis to the hippocampus.
Results/Discussion
VBM analysis shows significant clusters with increased grey matter volume in the hippocampus (cluster sizes 1531 and 3460, p < .001) when we compare the wheel vs locked wheel groups. Regarding the wheel vs no wheel comparison, significant clusters were observed in the hippocampus (cluster sizes 955 and 238, p < .001). Interestingly, no dierences were found when we compare the two control groups (locked wheel vs no wheel).
Conclusions
In this study, we replicate previous studies depicting an increased hippocampal volume under physical exercise in mice using VBM. Moreover, we certified here that attempting to study the impact of physical exercise on brain volume, control groups with a locked wheel or no wheel are equivalent.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/225755

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