Reference : Thyroid-disrupting chemicals and brain development: an update.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Thyroid-disrupting chemicals and brain development: an update.
Mughal, Bilal Babar mailto [Université de Liège - ULiège > > GIGA - Neurosciences >]
Fini, Jean-Baptiste [> >]
Demeneix, Barbara A. [> >]
Endocrine Connections
Yes (verified by ORBi)
United Kingdom
[en] endocrine disruptors ; neuroendocrinology ; thyroid
[en] This review covers recent findings on the main categories of thyroid hormone-disrupting chemicals and their effects on brain development. We draw mostly on epidemiological and experimental data published in the last decade. For each chemical class considered, we deal with not only the thyroid hormone-disrupting effects but also briefly mention the main mechanisms by which the same chemicals could modify estrogen and/or androgen signalling, thereby exacerbating adverse effects on endocrine-dependent developmental programmes. Further, we emphasize recent data showing how maternal thyroid hormone signalling during early pregnancy affects not only offspring IQ, but also neurodevelopmental disease risk. These recent findings add to established knowledge on the crucial importance of iodine and thyroid hormone for optimal brain development. We propose that prenatal exposure to mixtures of thyroid hormone-disrupting chemicals provides a plausible biological mechanism contributing to current increases in the incidence of neurodevelopmental disease and IQ loss.
Researchers ; Professionals ; Students ; General public
FP7 ; 607142 - DEVCOM - European Initial Training Network on Developmental and Computational Biology

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