[en] Type I collagen and DDR1 axis has been described to decrease cell proliferation
and to initiate apoptosis in non-invasive breast carcinoma in three-dimensional
cell culture matrices. Moreover, MT1-MMP down-regulates these effects. Here, we
address the effect of type I collagen aging and MT1-MMP expression on cell
proliferation suppression and induced-apoptosis in non-invasive MCF-7 and ZR-75-1
breast carcinoma. We provide evidence for a decrease in cell growth and an
increase in apoptosis in the presence of adult collagen when compared to old
collagen. This effect involves a differential activation of DDR1, as evidenced by
a higher DDR1 phosphorylation level in adult collagen. In adult collagen,
inhibition of DDR1 expression and kinase function induced an increase in cell
growth to a level similar to that observed in old collagen. The impact of aging
on the sensitivity of collagen to MT1-MMP has been reported recently. We used the
MT1-MMP expression strategy to verify whether, by degrading adult type I
collagen, it could lead to the same phenotype observed in old collagen 3D matrix.
MT1-MMP overexpression abrogated the proliferation suppression and
induced-apoptosis effects only in the presence of adult collagen. This suggests
that differential collagen degradation by MT1-MMP induced a structural
disorganization of adult collagen and inhibits DDR1 activation. This could in
turn impair DDR1-induced cell growth suppression and apoptosis. Taken together,
our data suggest that modifications of collagen structural organization, due to
aging, contribute to the loss of the growth suppression and induced apoptosis
effect of collagen in luminal breast carcinoma. MT1-MMP-dependent degradation and
aging of collagen have no additive effects on these processes.
Disciplines :
Oncology
Author, co-author :
Saby, Charles; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Rammal, Hassan; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Magnien, Kevin; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Buache, Emilie; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Brassart-Pasco, Sylvie; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Van-Gulick, Laurence; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Jeannesson, Pierre; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
Maquoi, Erik ✱; Université de Liège - ULiège > Département des sciences cliniques > GIGA-Cancer, Labo de biologie des tumeurs et du développement
Morjani, Hamid ✱; Université de Reims-Champagne-Ardenne, Reims, France > Unite de Formation et de Recherche (UFR) Pharmacie > Unite Mixte de Recherche (UMR) 7369 Matrice Extracellulaire et Dynamique Cellulaire
✱ These authors have contributed equally to this work.
Language :
English
Title :
Age-related modifications of type I collagen impair DDR1-induced apoptosis in non-invasive breast carcinoma cells
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