Poster (Scientific congresses and symposiums)
Integrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Emmanuel, Noémie; Mendoza Gallego, Carlos; Lismont, Marjorie
2017FROST6 - 6th conference on frontiers in organic synthesis tehnology
 

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Abstract :
[en] Development of photochemistry in macroscopic batch reaction vessels is hampered due to inherent limitations: light penetration remains superficial, resulting in inhomogeneous irradiation and hence to side-reactions or product degradation due to overexposure. The recent implementation of photochemical processes in microreactors under continuous-flow conditions appeared to be much more powerful than its batch analogue in terms of irradiation efficiency and light penetration. Furthermore, the fine control of residence time ensures an accurate control of the irradiation time, avoiding side-reactions and degradation. The scalable photooxidation of (L)-methionine with singlet oxygen using Rose Bengal as a sensitizer was successfully implemented in a microreactor setup and led to total and selective conversion into methionine sulfoxide, an important building block for the organic synthesis of peptides or functionalized amino acid. The reaction was performed in less than 1 min while the same reaction in batch took 2 h. Other substrates as α-terpinene or citronellol were also photooxidized into high added value compounds using the same conditions.
Disciplines :
Chemistry
Author, co-author :
Emmanuel, Noémie ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organométallique et catalyse homogène
Mendoza Gallego, Carlos ;  Université de Liège - ULiège > Department of Chemical Engineering > Génie chimique - Nanomatériaux et interfaces
Lismont, Marjorie ;  Université de Liège - ULiège > Département de physique > Biophotonique
Language :
English
Title :
Integrated continuous flow photoreactors: Photooxidation of (L)-methionine with singlet oxygen
Publication date :
19 October 2017
Event name :
FROST6 - 6th conference on frontiers in organic synthesis tehnology
Event organizer :
Flow Chemistry Society
Event place :
Budapest, Hungary
Event date :
du 18 octobre 2017 au 20 octobre 2017
Audience :
International
Available on ORBi :
since 28 May 2018

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