Reference : Quelle place pour les diuretiques thiazidiques et apparentes chez les patients diabet...
Scientific journals : Article
Human health sciences : Urology & nephrology
Human health sciences : Pharmacy, pharmacology & toxicology
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/223517
Quelle place pour les diuretiques thiazidiques et apparentes chez les patients diabetiques de type 2 ?
French
[en] Which place for thiazide and thiazide-like diuretics in patients with type 2 diabetes ?
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Krzesinski, Jean-Marie mailto [Université de Liège - ULiège > Département des sciences cliniques > Néphrologie >]
2018
Revue Médicale de Liège
73
4
176-182
Yes (verified by ORBi)
0370-629X
Belgium
[en] Chlorthalidone ; Diuretic ; Heart failure ; Hypertension ; Indapamide ; Thiazide ; Type 2 diabetes ; Cardiovascular disease
[en] The use of thiazides as antihypertensive agents has been challenged because associated metabolic adverse events, including new-onset diabetes. However, these metabolic disturbances are less marked with low-dose of hydrochlorothiazide and with thiazide-like diuretics such as chlorthalidone and indapamide. In post hoc analyses of subgroups of patients with hypertension and type 2 diabetes, thiazide(-like) diuretics resulted in a significant reduction in cardiovascular events, all-cause mortality and hospitalization for heart failure compared to placebo. Furthermore, they were shown to be non-inferior to other antihypertensive agents, including blockers of the renin-angiotensin system in diabetic patients without albuminuria. Benefits attributed to thiazide(-like) diuretics (especially at low dose) in terms of cardiovascular protection outweigh the risk of worsening glucose control and inducing other metabolic disorders in patients with type 2 diabetes. Thus low dose thiazide(-like) drugs still play a major role in the treatment of hypertension in patients with type 2 diabetes.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/223517
https://www.rmlg.ulg.ac.be

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