Paper published in a book (Scientific congresses and symposiums)
Group B Streptococcus neonatal invasive infections in Belgium, 2013-2016
MELIN, Pierrette; LECOMTE, Laurie; SACHELI, Rosalie et al.
2018In Abstract book of 1st ISSAD 2018
Peer reviewed
 

Files


Full Text
ISSAD 2018 poster clinical GBS neonatal disease.pdf
Publisher postprint (194 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Group B streptococcus; Neonatal invasive disease; Belgium
Abstract :
[en] Background Since 2003, intrapartum antimicrobialprophylaxis (IAP) based on a universal screening for group B streptococcus (GBS) colonization at 35-37 weeks’ gestation is recommended in Belgium. Following, a decrease in the incidence of early-onset disease (EOD) was observed whereas late onset disease (LOD) have not changed. We describe the clinical and bacteriological characteristics of GBS neonatal invasive infections reported to the Belgian National Reference Centre (NRC) for GBS from 2013 to mid 2016. Methods On a voluntary base, all laboratories located in Belgium are invited to notify GBS neonatal invasive disease to the NRC, to send the isolate and fill a case-report questionnaire. This surveillance includes cases from 01.2013 to 07.2016. Following confirmation of identification, capsular-typing was performed by both agglutination and with PCR. Results Data from 157 GBS invasive neonatal cases were analysed: according to age at onset there were 70 EOD (median: day 0) and 57 LOD (median: 28 days). Among EOD cases, a male/female ratio was 0.75. The major types were III (35.7%), followed by Ia, II, V, Ib, IV, VI (20%, 14.3%, 12.9%, 10%, <10%). Fever and respiratory distress were frequently reported at onset. Meningitis was notified for 10,7% of cases. Among LOD cases, male/female ratio was 0.86. The predominant type was III (71.6%), followed mainly by Ia (13.4%). Gestational age at birth was significantly lower for LO cases and twins more frequent. The predominant characteristic at onset was fever and 32.5% developed meningitis. One death was reported in both groups of EOD and LOD. Antenatal GBS screening results and IAP were also analysed in regard to age at onset of diseases. Conclusions Clinical presentations were associated with age at onset of infection. Serotype III predominated in neonatal infections. Positive antenatal screening and appropriate IAP were not always protective for EOD and of course not for LOD.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pediatrics
Public health, health care sciences & services
Laboratory medicine & medical technology
Immunology & infectious disease
Author, co-author :
MELIN, Pierrette  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
LECOMTE, Laurie
SACHELI, Rosalie  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
DESCY, Julie ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
HUYNEN, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
HAYETTE, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
MEEX, Cécile ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
Language :
English
Title :
Group B Streptococcus neonatal invasive infections in Belgium, 2013-2016
Publication date :
2018
Event name :
1st International Symposium on Streptococcus agalactiae Disease (ISSAD)
Event organizer :
Bill & Melinda Gates foundation
W.H.O.
Event place :
Cape Town, South Africa
Event date :
20th – 23rd February 2018
Audience :
International
Main work title :
Abstract book of 1st ISSAD 2018
Peer reviewed :
Peer reviewed
Funders :
The national reference centre is partially supported by the Belgian Ministry of Social Affairs through a fund within the health insurance system
Available on ORBi :
since 16 May 2018

Statistics


Number of views
139 (4 by ULiège)
Number of downloads
38 (2 by ULiège)

Bibliography


Similar publications



Contact ORBi