Reference : Usefulness of Serial B-type natriuretic peptide assessment in asymptomatic aortic stenosis
Scientific journals : Article
Human health sciences : Cardiovascular & respiratory systems
http://hdl.handle.net/2268/222593
Usefulness of Serial B-type natriuretic peptide assessment in asymptomatic aortic stenosis
English
Henri, C. [Departments of Cardiology and Radiology, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium, Department of Medicine, University of Montreal, Montreal Heart Institute, Montreal, Canada]
Magne, J. [Departments of Cardiology and Radiology, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium]
DULGHERU, Raluca Elena [Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie >]
DAVIN, Laurent mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de cardiologie >]
Laaraibi, S. [Departments of Cardiology and Radiology, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium]
Voilliot, D. [Departments of Cardiology and Radiology, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium]
Kou, S. [Departments of Cardiology and Radiology, University of Liège, Centre Hospitalier Universitaire Sart Tilman, Liège, Belgium]
Nchimi Longang, Alain mailto [Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation >]
Oury, Cécile mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences >]
Pierard, Luc mailto [Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques >]
Lancellotti, Patrizio mailto [Université de Liège - ULiège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie >]
2014
American Journal of Cardiology
Elsevier Inc.
114
3
441-448
Yes (verified by ORBi)
0002-9149
1879-1913
[en] Doppler echocardiography ; Aged ; Aortic Valve Stenosis ; Biological Markers ; Echocardiography, Doppler ; Female ; Follow-Up Studies ; Humans ; Male ; Natriuretic Peptide, Brain ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Risk Assessment ; Severity of Illness Index ; Time Factors ; Ventricular Function, Left
[en] B-type natriuretic peptide (BNP) level may be a useful prognostic marker for the management of asymptomatic patients with aortic stenosis (AS). The aim of this study was to identify the echocardiographic determinants of BNP changes during follow-up in AS. We studied 61 asymptomatic patients with greater than moderate AS and preserved left ventricular (LV) ejection fraction who underwent rest and exercise Doppler echocardiography with concomitant BNP level measurement at baseline. BNP measurement was repeated after inclusion every 6 months. Patients were divided into 2 groups according to the median of BNP changes during follow-up. According to parameters at rest, patients in the high BNP changes group had significantly higher E/e′ ratio. Statistically significant correlations were found between BNP changes and E/e′ ratio and indexed left atrial area. According to exercise parameters, patients in the high BNP changes group had significantly lower exercise-induced increase in LV ejection fraction. Statistically significant correlations were found between BNP changes and exercise-induced changes in LV ejection fraction. After adjustment for age, mean aortic pressure gradient, and BNP level at baseline, multivariate analysis identified indexed left atrial area, E/e′ at rest, and exercise-induced increase in ejection fraction as independent determinants of BNP changes during follow-up. In conclusion, this study shows that, in asymptomatic patients with preserved LV function and moderate AS, serial BNP measurements may widely vary. Subclinical LV diastolic and systolic dysfunctions are frequently present in patients with higher serial BNP changes. © 2014 Elsevier Inc. All rights reserved.
http://hdl.handle.net/2268/222593
10.1016/j.amjcard.2014.04.053

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