Validation of the inflammatory bowel disease disability index in a population-based cohort

Article; Crohn disease; Crohn Disease Activity Index; Frenchman; Adult; Colitis, Ulcerative; Disability Evaluation; Female; Humans; Male; Prospective Studies; Reproducibility of Results; Severity of Illness Index; Sex Factors; Surveys and Questionnaires; Time Factors; Young Adult

Abstract :

[en] Background: IBDs are chronic destructive disorders that negatively affect the functional status of patients. Recently, the Inflammatory Bowel Disease Disability Index (IBD-DI) was developed according to standard WHO processes. The aims of the current study were to validate the IBD-DI in an independent patient cohort, to develop an index-specific scoring system and to describe the disability status of a well-defined population-based cohort of French patients with IBD. Methods: From February 2012 to March 2014, the IBD-DI questionnaire was administered to a random sample of adult patients with an established diagnosis of IBD issued from a French population-based registry. The IBD-DI consists of 28 items that evaluate the four domains of body functions, activity participation, body structures and environmental factors. Validation included item reduction and data structure, construct validity, internal consistency, interobserver and intraobserver reliability evaluations. Results: 150 patients with Crohn's disease (CD) and 50 patients with UC completed the IBD-DI validation phase. The intraclass correlation coefficient for interobserver reliability was 0.91 and 0.54 for intraobserver reliability. Cronbach's α of internal consistency was 0.86. IBD-DI scores varied from 0 to 100 with a mean of 35.3 (Q1=19.6; Q3=51.8). IBD-DI scores were highly correlated with Inflammatory Bowel Disease Questionnaire (-0.82; p<0.001) and SF-36 (-0.61; p<0.05) scores. Female gender (p<0.001), clinical disease activity (p<0.0001) and disease duration (p=0.02) were associated with higher IBD-DI scores. Conclusions: The IBD-DI has been validated for use in clinical trials and epidemiological studies. The IBD-DI showed high internal consistency, interobserver reliability and construct validity, and a moderate intraobserver reliability. It comprises 14 questions and ranges from 0 to 100. The mean IBD-DI score was 35.3 and was associated with gender, clinical disease activity and disease duration. Further research is needed to confirm the structural validity and to assess the responsiveness of IBD-DI. Trial registration number: 2011-A00877-34. © 2017, BMJ Publishing Group. All rights reserved.

Disciplines :

Gastroenterology & hepatology

Author, co-author :

Gower-Rousseau, C.; Public Health, Epidemiology and Economic Health, Registre Epimad, Maison Régionale de La Recherche Clinique, Centre Hospitalier Universitaire Régional, Lille Cedex, France, Lille Inflammation Research International Center LIRIC - UMR 995 Inserm/Université Lille 2/CHRU de Lille, Equipe IBD and Environmental Factors: Epidemiology and Functional Analyses, Lille University, France

Sarter, H.; Public Health, Epidemiology and Economic Health, Registre Epimad, Maison Régionale de La Recherche Clinique, Centre Hospitalier Universitaire Régional, Lille Cedex, France, Lille Inflammation Research International Center LIRIC - UMR 995 Inserm/Université Lille 2/CHRU de Lille, Equipe IBD and Environmental Factors: Epidemiology and Functional Analyses, Lille University, France

Savoye, G.; Gastroenterology Unit, Epimad Registry, Hôpital Charles Nicolle, Rouen University Hospital, Rouen, France

Tavernier, N.; Gastroenterology Unit, Hôpital Huriez, Lille University Hospital, France

Fumery, M.; Gastroenterology Unit, Epimad Registry, CHU Amiens Sud, Amiens University Hospital, Avenue Laennec-Salouel, France

Sandborn, W. J.; Division of Gastroenterology, University of California San Diego, San Diego, CA, United States

Feagan, B. G.; University of Western Ontario, London, ON, Canada

Duhamel, A.; Univ. Lille, CHU Lille, EA 2694 - Santé Publique : Épidémiologie et Qualité des Soins, Lille, France

Guillon-Dellac, N.; Public Health, Epidemiology and Economic Health, Registre Epimad, Maison Régionale de La Recherche Clinique, Centre Hospitalier Universitaire Régional, Lille Cedex, France, Lille Inflammation Research International Center LIRIC - UMR 995 Inserm/Université Lille 2/CHRU de Lille, Equipe IBD and Environmental Factors: Epidemiology and Functional Analyses, Lille University, France

Colombel, J.-F.; Icahn School of Medicine at Mount Sinai, New York, NY, United States

More authors (31 more)

Language :

English

Title :

Validation of the inflammatory bowel disease disability index in a population-based cohort

Publication date :

2017

Journal title :

Gut

ISSN :

0017-5749

eISSN :

1468-3288

Publisher :

BMJ Publishing Group

Volume :

Issue :

Pages :

588-596

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://doi.org/10.1136/GUTJNL-2015-310151

Name of the research project :

Programme Hospitalier de Recherche Clinique Inter Regional» 2011

Funders :

INSERM - Institut National de la Santé et de la Recherche Médicale [FR]
AFA - Association François Aupetit [FR]
Ministère de la Santé et de la Prévention [FR]
AbbVie [BE]

Available on ORBi :

since 23 March 2018

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