Reference : Redox regulation of nuclear post-translational modifications during NF-kappaB activation.
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Redox regulation of nuclear post-translational modifications during NF-kappaB activation.
Gloire, Geoffrey mailto [Université de Liège - ULiège > > GIGA-R : Virologie - Immunologie >]
Piette, Jacques mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie - Immunologie - Département des sciences de la vie - GIGA-Research >]
Antioxidants & Redox Signaling
Mary Ann Liebert, Inc.
Yes (verified by ORBi)
[en] NF-kB ; ROS ; Post-translational modifications
[en] The transcription factor NF-kappaB controls the expression of hundreds of genes involved in the regulation of the immune/inflammatory response, development, and apoptosis. In resting cells, NF-kappaB proteins are sequestered in the cytoplasm through their tight association with IkappaB proteins. NF-kappaB activation relies on the signal-induced IkappaB phosphorylation and degradation, thereby allowing the nuclear translocation of NF-kappaB proteins. In the nucleus, several post-translational modifications of NF-kappaB and chromatin remodeling of target genes are mandatory for NF-kappaB DNA binding and full transcription. Since 1991, reactive oxygen species (ROS) have been implicated in NF-kappaB activation. ROS enhance the cytoplasmic signaling pathways leading to NF-kappaB nuclear translocation, but reduction/oxidation (redox) also controls several key steps in the nuclear phase of the NF-kappaB program, including chromatin remodeling, recruitment of co-activators, and DNA binding. Here we describe the redox regulation of NF-kappaB activity in the nucleus.
Researchers ; Professionals

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