No full text
Article (Scientific journals)
Genetic Association of Bovine Lymphocyte Antigen DRB3 Alleles with Immunological Traits of Holstein Cattle
Dietz, A.B.; Detilleux, Johann; Freeman, A.E. et al.
1997In Journal of Dairy Science, 80 (2), p. 400-405
Peer Reviewed verified by ORBi
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] The associations between alleles at the BoLA (bovine lymphocyte antigen) DRB3 locus and 20 indicator traits of innate and adaptive immunity were investigated. Periparturient Holsteins (n = 127) were genotyped at the BoLA DRB3 locus using polymerase chain reaction and restriction fragment length polymorphism. Twenty-two alleles were observed in the study population, and frequencies ranged from 21 to <1%. The same cattle were tested for a total of 20 innate and adaptive immunity traits, including lymphocyte response to mitogens (proliferative responses and Ig secretion), serum Ig, complement and conglutinin concentrations, total leukocyte count, and selected assays for neutrophil function. Models with gene substitution effects were used to investigate associations between BoLA DRB3 alleles and each of the immunological variables. Significant associations were found with 13 of the leukocyte functions tested. The number of immune parameters with significant associations with any allele ranged from 0 (with alleles DRB3.2*23 and DRB3.2*27) to 7 (with DRB3.2*8). The immunological parameter that had the most associations with alleles was serum IgG2 concentration with 6 alleles. One group of 4 alleles (representing 46% of the total allele frequency) was uniformly associated with increased IgM and complement and decreased mononuclear cell numbers. Thus, we demonstrated that the BoLA DRB3 genotype can influence measures of innate and adaptive immunity.
Disciplines :
Animal production & animal husbandry
Author, co-author :
Dietz, A.B.
Detilleux, Johann ;  Université de Liège > Département des productions animales (DPA) > Génétique quantitative
Freeman, A.E.
Stabel, J.R.
Kehrli, Jr.M.E.
Language :
English
Title :
Genetic Association of Bovine Lymphocyte Antigen DRB3 Alleles with Immunological Traits of Holstein Cattle
Publication date :
February 1997
Journal title :
Journal of Dairy Science
ISSN :
0022-0302
eISSN :
1525-3198
Publisher :
American Dairy Science Association, Champaign, United States - Illinois
Volume :
80
Issue :
2
Pages :
400-405
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 01 March 2018

Statistics


Number of views
39 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
87
Scopus citations®
without self-citations
80
OpenCitations
 
60

Bibliography


Similar publications



Contact ORBi