Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial

[en] Objective: Epidemiological and experimental studies have suggested that lipid disorders might be involved in the pathophysiology of knee osteoarthritis (OA). Studies assessing the effect of statins on knee OA progression have shown conflicting results. We investigated the impact of statin use on radiological progression in patients with radiological and symptomatic knee OA. Methods: In total, 336 patients from the placebo arm of SEKOIA trial completed the 3-year follow-up and were included in this post-hoc analysis. Statin use was recorded at baseline interview. Minimal medial tibiofemoral joint space was measured on plain radiographs by an automated method at baseline and then annually. Radiologic progression was defined as joint space narrowing. ≥. 0.5. mm over 3 years. Results: Overall, 71 patients were statin users (21.1%). They had a higher BMI (31.1±5.3 vs. 29.3±5.2kg/m2, P =0.008), a higher sum of metabolic factors (≥3 factors: 43.7% vs 7.2%; P for trend<0.001) and a higher rate of radiological progression (49.3% vs. 32.1%, P =0.007) as compared to statin non-users. The significant association between radiological progression and statin use was independent of age, gender, WOMAC global score, disease duration, baseline joint space width, hypertension, type 2 diabetes, obesity (BMI>30kg/m2) and cardiovascular diseases [relative risk 1.49 (95% CI: 1.10-2.02), P =0.010]. Conclusion: Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity). © 2017 Société française de rhumatologie.

Disciplines :

General & internal medicine
Public health, health care sciences & services

Author, co-author :

Eymard, F.; Department of rheumatology, Henri-Mondor hospital, AP-HP, 94010 Créteil cedex, France

Parsons, C.; MRC lifecourse epidemiology unit, Southampton general hospital, Southampton SO16 6YD, UK

Edwards, M. H.; MRC lifecourse epidemiology unit, Southampton general hospital, Southampton SO16 6YD, UK

Petit-Dop, F.; Innovative pole of rheumatology, Servier, 92150 Suresnes, France

Reginster, Jean-Yves ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Bruyère, Olivier ; Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé

Chevalier, X.; Department of rheumatology, Henri-Mondor hospital, AP-HP, 94010 Créteil cedex, France

Cooper, Cyrus; MRC lifecourse epidemiology unit, Southampton general hospital, Southampton SO16 6YD, UK

Richette, P.; Department of rheumatology, Lariboisière hospital, AP-HP, 75475 Paris cedex 10, France, Inserm U1132, university Paris 7, Lariboisière hospital, AP-HP, 75475 Paris cedex 10, France

Language :

English

Title :

Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial

Publication date :

2018

Journal title :

Joint Bone Spine

ISSN :

1297-319X

eISSN :

1778-7254

Publisher :

Elsevier Masson SAS

Volume :

Issue :

Pages :

609-614

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 21 February 2018

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