Reference : Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of t...
Scientific journals : Article
Human health sciences : General & internal medicine
http://hdl.handle.net/2268/220599
Statin use and knee osteoarthritis progression: Results from a post-hoc analysis of the SEKOIA trial
English
Eymard, F. [Department of rheumatology, Henri-Mondor hospital, AP-HP, 94010 Créteil cedex, France]
Parsons, C. [MRC lifecourse epidemiology unit, Southampton general hospital, Southampton SO16 6YD, UK]
Edwards, M. H. [MRC lifecourse epidemiology unit, Southampton general hospital, Southampton SO16 6YD, UK]
Petit-Dop, F. [Innovative pole of rheumatology, Servier, 92150 Suresnes, France]
Reginster, Jean-Yves mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Bruyère, Olivier mailto [Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé >]
Chevalier, X. [Department of rheumatology, Henri-Mondor hospital, AP-HP, 94010 Créteil cedex, France]
Cooper, C. [MRC lifecourse epidemiology unit, Southampton general hospital, Southampton SO16 6YD, UK]
Richette, P. [Department of rheumatology, Lariboisière hospital, AP-HP, 75475 Paris cedex 10, France, Inserm U1132, university Paris 7, Lariboisière hospital, AP-HP, 75475 Paris cedex 10, France]
2017
Joint Bone Spine
Elsevier Masson SAS
Yes (verified by ORBi)
International
1297-319X
1778-7254
[en] Dyslipidemia ; Knee osteoarthritis ; Radiological progression ; Statin
[en] Objective: Epidemiological and experimental studies have suggested that lipid disorders might be involved in the pathophysiology of knee osteoarthritis (OA). Studies assessing the effect of statins on knee OA progression have shown conflicting results. We investigated the impact of statin use on radiological progression in patients with radiological and symptomatic knee OA. Methods: In total, 336 patients from the placebo arm of SEKOIA trial completed the 3-year follow-up and were included in this post-hoc analysis. Statin use was recorded at baseline interview. Minimal medial tibiofemoral joint space was measured on plain radiographs by an automated method at baseline and then annually. Radiologic progression was defined as joint space narrowing. ≥. 0.5. mm over 3 years. Results: Overall, 71 patients were statin users (21.1%). They had a higher BMI (31.1±5.3 vs. 29.3±5.2kg/m2, P =0.008), a higher sum of metabolic factors (≥3 factors: 43.7% vs 7.2%; P for trend<0.001) and a higher rate of radiological progression (49.3% vs. 32.1%, P =0.007) as compared to statin non-users. The significant association between radiological progression and statin use was independent of age, gender, WOMAC global score, disease duration, baseline joint space width, hypertension, type 2 diabetes, obesity (BMI>30kg/m2) and cardiovascular diseases [relative risk 1.49 (95% CI: 1.10-2.02), P =0.010]. Conclusion: Among patients with knee OA, statin use was associated with radiological worsening over 3 years, regardless of other potential confounding factors (obesity, type 2 diabetes, hypertension, disease duration, symptom intensity and radiological severity). © 2017 Société française de rhumatologie.
Novartis; MSD, Merck Sharp and Dohme; Sanofi; Amgen; Eli Lilly and Company; Roche; GSK, GlaxoSmithKline foundation; Bayer; BMS, Bristol-Myers Squibb; Genzyme; NPS, National Park Service; Merck; GSK, GlaxoSmithKline; Medtronic; BMS, Bristol-Myers Squibb; MSD, Meso Scale Diagnostics
http://hdl.handle.net/2268/220599
10.1016/j.jbspin.2017.09.014

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