Article (Scientific journals)
Osteoarthritis increases the risk of cardiovascular disease: Data from the osteoarthritis initiative
Veronese, N.; Stubbs, B.; Solmi, M. et al.
2018In Journal of Nutrition, Health and Aging, 22 (3), p. 371-376
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Keywords :
Osteoarthritis; Cardiovascular disease; epidemiology
Abstract :
[en] Objectives: Although osteoarthritis (OA) is a common condition in older adults, the role of OA in increasing cardiovascular disease (CVD) incidence is still debated. The aim of this study was to investigate the association between OA and the onset of CVD in a large database of American adults. Design: Longitudinal. Setting: Community-dwelling. Participants: People with OA or at high risk of OA. Measurements: Osteoarthritis was defined as the presence of OA of the hand, knee, hip, back/neck or of other sites. CVD was defined as self-reported presence of heart attack, heart failure, stroke and other cerebral atherosclerotic conditions, and peripheral artery disease. Results: A total 4,265 persons without CVD (mean age=60.8 years, females=59.2%) at baseline were analyzed (1,775 with OA versus 2,490 without). Over a mean of 8.2 years, according to an adjusted Cox’s regression analysis for 11 potential baseline confounders, study participants with OA of any joint had a significantly higher risk of developing CVD compared to those without OA (Hazard ratio (HR): =1.27; 95% CI: 1.03-1.56). The presence of hand OA was associated with a higher risk of developing CVD (HR=1.31; 95%CI: 1.01-1.68) with respect to those who had no OA. Knee, hip and back/neck OA did not, instead, increase the risk of developing CVD. The association between OA and CVD was significant in the women, but not in the men. Conclusions: OA, in particular, when it affects the hand and in women, was associated with a higher risk of developing CVD. © 2017 Serdi and Springer-Verlag France SAS
Disciplines :
General & internal medicine
Author, co-author :
Veronese, N.;  National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, Padova, Italy, Institute for clinical Research and Education in Medicine (IREM), Padova, Italy
Stubbs, B.;  Physiotherapy Department, South London and Maudsley NHS FoundationTrust, Denmark Hill, London, United Kingdom, Health Service and Population Research Department, Institute of Psychiatry, King’s College London, De Crespigny Park, London, United Kingdom
Solmi, M.;  Institute for clinical Research and Education in Medicine (IREM), Padova, Italy, Department of Neurosciences, University of Padova, Padova, Italy
Smith, T. O.;  Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, United Kingdom
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Maggi, S.;  National Research Council, Neuroscience Institute, Aging Branch, Via Giustiniani, 2, Padova, Italy
Language :
English
Title :
Osteoarthritis increases the risk of cardiovascular disease: Data from the osteoarthritis initiative
Publication date :
2018
Journal title :
Journal of Nutrition, Health and Aging
ISSN :
1279-7707
eISSN :
1760-4788
Publisher :
Springer-Verlag France
Volume :
22
Issue :
3
Pages :
371-376
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 21 February 2018

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