Aptamers as radiopharmaceuticals for nuclear imaging and therapy

[en] Today, radiopharmaceuticals belong to the standard instrumentation of nuclear medicine, both in the context of diagnosis and therapy. The majority of radiopharmaceuticals consist of targeting biomolecules which are designed to interact with a disease-related molecular target. A plethora of targeting biomolecules of radiopharmaceuticals exists, including antibodies, antibody fragments, proteins, peptides and nucleic acids. Nucleic acids have some significant advantages relative to proteinaceous biomolecules in terms of size, production, modifications, possible targets and immunogenicity. In particular, aptamers (non-coding, synthetic, single-stranded DNA or RNA oligonucleotides) are of interest because they can bind a molecular target with high affinity and specificity. At present, few aptamers have been investigated preclinically for imaging and therapeutic applications. In this review, we describe the use of aptamers as targeting biomolecules of radiopharmaceuticals. We also discuss the chemical modifications which are needed to turn aptamers into valuable (radio-)pharmaceuticals, as well as the different radiolabeling strategies that can be used to radiolabel oligonucleotides and, in particular, aptamers. © 2015 Elsevier Inc.

Disciplines :

Biotechnology

Author, co-author :

Gijs, M.; Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium, Cyclotron Research Centre, University of Liège, Liège, Belgium

Aerts, A.; Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium

Impens, N.; Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium

Baatout, S.; Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium

Luxen, André ; Université de Liège - ULiège > Centre de Recherches du Cyclotron

Title :

Aptamers as radiopharmaceuticals for nuclear imaging and therapy

Publication date :

2016

Journal title :

Nuclear Medicine and Biology

ISSN :

0969-8051

Publisher :

Elsevier Inc.

Volume :

Issue :

Pages :

253-271

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 20 February 2018

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