Article (Scientific journals)
Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.
Rambout, Xavier; Dequiedt, Franck; Maquat, Lynne E.
2017In Chemical Reviews
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Abstract :
[en] Whereas individual steps of protein-coding gene expression in eukaryotes can be studied in isolation in vitro, it has become clear that these steps are intimately connected within cells. Connections not only ensure quality control but also fine-tune the gene expression process, which must adapt to environmental changes while remaining robust. In this review, we systematically present proven and potential mechanisms by which sequence-specific DNA-binding transcription factors can alter gene expression beyond transcription initiation and regulate pre-mRNA splicing, and thereby mRNA isoform production, by (i) influencing transcription elongation rates, (ii) binding to pre-mRNA to recruit splicing factors, and/or (iii) blocking the association of splicing factors with pre-mRNA. We propose various mechanistic models throughout the review, in some cases without explicit supportive evidence, in hopes of providing fertile ground for future studies.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Rambout, Xavier
Dequiedt, Franck  ;  Université de Liège - ULiège > GIGA-Research
Maquat, Lynne E.
Language :
English
Title :
Beyond Transcription: Roles of Transcription Factors in Pre-mRNA Splicing.
Publication date :
2017
Journal title :
Chemical Reviews
ISSN :
0009-2665
eISSN :
1520-6890
Publisher :
American Chemical Society, Washington, United States - District of Columbia
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2018

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