Article (Scientific journals)
Neonatal screening improves sickle cell disease clinical outcome in Belgium.
Lê, Phu-Quoc; Ferster, A; Dedeken, L et al.
2018In Journal of Medical Screening, 25 (2), p. 57-63
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Keywords :
Sickle cell disease; hospitalization; infection; neonatal screening programme
Abstract :
[en] Objectives To compare the outcomes of sickle cell disease patients diagnosed through neonatal screening with those who were not. Methods In an observational multicenter study in Belgium, 167 screened and 93 unscreened sickle cell disease patients were analyzed for a total of 1116 and 958 patient-years of follow-up, respectively. Both groups were compared with propensity score analysis, with patients matched on three covariates (gender, genotype, and central Africa origin). Bonferroni correction was applied for all comparisons. Results Kaplan-Meier estimates of survival without bacteremia were significantly higher in the screened group than the unscreened group (94.47%; [95% CI, 88.64-97.36%] versus 83.78% [95% CI, 72.27-90.42%]), p = 0.032. Non-significant differences between both groups were reported for survival without acute chest syndrome, acute anemia, cerebral complication, severe infection, and vaso-occlusive crisis. Significantly lower hospitalization rate and days per 100 patient-years were observed in the screened compared with the unscreened group (0.27 vs. 0.63 and 1.25 vs. 2.82, p = 0.0006 and <0.0001). Conclusion These data confirm the benefit of a neonatal screening programme in reducing bacteremia and hospitalization.
Disciplines :
Pediatrics
Hematology
Author, co-author :
Lê, Phu-Quoc
Ferster, A
Dedeken, L
Vermylen, C
Vanderfaeillie, A
Rozen, L
Heijmans, C
Huybrechts, S
Devalck, C
Cotton, F
Ketelslegers, O
Dresse, Marie-Françoise ;  Centre Hospitalier Universitaire de Liège - CHU > Department of Pediatrics,University Hospital Liège > CHR Citadelle, Liège, Belgium
Fils, JF
Gulbis, B
More authors (4 more) Less
Language :
English
Title :
Neonatal screening improves sickle cell disease clinical outcome in Belgium.
Publication date :
2018
Journal title :
Journal of Medical Screening
ISSN :
0969-1413
eISSN :
1475-5793
Publisher :
Royal Society of Medicine Press Limited, London, United Kingdom
Volume :
25
Issue :
2
Pages :
57-63
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 26 January 2018

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