Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI
Quantitative longitudinal imaging of activated microglia as a marker of inflammation in the pilocarpine rat model of epilepsy using [11C]-(R)-PK11195 PET and MRI
Publication date :
2016
Journal title :
Journal of Cerebral Blood Flow and Metabolism
ISSN :
0271-678X
eISSN :
1559-7016
Publisher :
Nature Publishing Group, New York, United States - New York
Aronica E and Crino PB. Inflammation in epilepsy: clinical observations. Epilepsia 2011; 52(Suppl 3): 26-32.
Ravizza T, Balosso S and Vezzani A. Inflammation and prevention of epileptogenesis. Neurosci Lett 2011; 497: 223-230.
Vezzani A, Aronica E, Mazarati A, et al. Epilepsy and brain inflammation. Exp Neurol 2013; 244: 11-21.
Vezzani A, Auvin S, Ravizza T, et al. Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators. In: Noebels JL, et al. (eds) Jasper’s basic mechanisms of the epilepsies. Bethesda, MD: National Center for Biotechnology Information, 2012.
Bogdanovic RM, Syvanen S, Michler C, et al. (R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model. Neuropharmacology 2014; 85: 104-112.
Dedeurwaerdere S, Callaghan PD, Pham T, et al. PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy. EJNMMI Res 2012; 2: 60.
Ravizza T, Gagliardi B, Noe F, et al. Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 2008; 29: 142-160.
Matthews PM and Datta G. Positron-emission tomography molecular imaging of glia and myelin in drug discovery for multiple sclerosis. Expert Opin Drug Discov 2015; 10: 557-570.
Benavides J, Capdeville C, Dauphin F, et al. The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration. Brain Res 1990; 522: 275-289.
Brown A. Understanding the MIND phenotype: macrophage/ microglia inflammation in neurocognitive disorders related to human immunodeficiency virus infection. Clin Transl Med 2015; 4: 7.
Harhausen D, Sudmann V, Khojasteh U, et al. Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke. PLoS One 2013; 8: e69529.
Park E, Gallezot JD, Delgadillo A, et al.11C-PBR28 imaging in multiple sclerosis patients and healthy controls: test-retest reproducibility and focal visualization of active white matter areas. Eur J Nucl Med Mol Imaging 2015; 42: 1081-1092.
Zurcher NR, Loggia ML, Lawson R, et al. Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28. Neuroimage Clin 2015; 7: 409-414.
Banati RB, Newcombe J, Gunn RN, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain 2000; 123(Pt 11): 2321-2337.
Pappata S, Levasseur M, Gunn RN, et al. Thalamic microglial activation in ischemic stroke detected in vivo by PET and [11C]PK11195. Neurology 2000; 55: 1052-1054.
Walter HL, Walberer M, Rueger MA, et al. In vivo analysis of neuroinflammation in the late chronic phase after experimental stroke. Neuroscience 2015; 292: 71-80.
Yasuno F, Ota M, Kosaka J, et al. Increased binding of peripheral benzodiazepine receptor in Alzheimer’s disease measured by positron emission tomography with [11C]DAA1106. Biol Psychiatry 2008; 64: 835-841.
Ramlackhansingh AF, Brooks DJ, Greenwood RJ, et al. Inflammation after trauma: microglial activation and traumatic brain injury. Ann Neurol 2011; 70: 374-383.
Weissman BA and Raveh L. Peripheral benzodiazepine receptors: on mice and human brain imaging. J Neurochem 2003; 84: 432-437.
Amhaoul H, Hamaide J, Bertoglio D, et al. Brain inflammation in a chronic epilepsy model: evolving pattern of the translocator protein during epileptogenesis. Neurobiol Dis 2015; 82: 526-539.
Guidelines for epidemiologic studies on epilepsy. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Epilepsia 1993; 34: 592-596.
Banati RB, Goerres GW, Myers R, et al. [11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen’s encephalitis. Neurology 1999; 53: 2199-2203.
Butler T, Ichise M, Teich AF, et al. Imaging inflammation in a patient with epilepsy due to focal cortical dysplasia. J Neuroimaging 2013; 23: 129-131.
Hirvonen J, Kreisl WC, Fujita M, et al. Increased in vivo expression of an inflammatory marker in temporal lobe epilepsy. J Nucl Med 2012; 53: 234-240.
Owen DR, Howell OW, Tang SP, et al. Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation. J Cereb Blood Flow Metab 2010; 30: 1608-1618.
Venneti S, Lopresti BJ and Wiley CA. The peripheral benzodiazepine receptor (Translocator protein 18 kDa) in microglia: from pathology to imaging. Prog Neurobiol 2006; 80: 308-322.
Bajorat R, Wilde M, Sellmann T, et al. Seizure frequency in pilocarpine-treated rats is independent of circadian rhythm. Epilepsia 2011; 52: e118-e122.
Nadam J, Navarro F, Sanchez P, et al. Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus. Neurobiol Dis 2007; 25: 412-426.
Racine RJ. Modification of seizure activity by electrical stimulation. I. After-discharge threshold. Electroencephalogr Clin Neurophysiol 1972; 32: 269-279.
Turkheimer FE, Edison P, Pavese N, et al. Reference and target region modeling of [11C]-(R)-PK11195 brain studies. J Nucl Med 2007; 48: 158-167.
Jenkinson M, Beckmann C, Woolrich MW, et al. FSL. Neuroimage 2012; 62: 782-790.
Heckemann RA, Keihaninejad S, Aljabar P, et al. Improving intersubject image registration using tissueclass information benefits robustness and accuracy of multi-atlas based anatomical segmentation. Neuroimage 2010; 51: 221-227.
Lancelot S, Roche R, Slimen A, et al. A multi-atlas based method for automated anatomical rat brain MRI segmentation and extraction of PET activity. PLoS One 2014; 9: e109113.
Modat M, Ridgway GR, Taylor ZA, et al. Fast free-form deformation using graphics processing units. Comput Methods Programs Biomed 2010; 98: 278-284.
Logan J, Fowler JS, Volkow ND, et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab 1990; 10: 740-747.
Logan J, Fowler JS, Volkow ND, et al. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab 1996; 16: 834-840.
Lammertsma AA and Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage 1996; 4(3 Pt 1): 153-158.
Klein S, Bankstahl M and Loscher W. Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. Neuropharmacology 2015; 90: 9053-9062.
Raposo C and Schwartz M. Glial scar and immune cell involvement in tissue remodeling and repair following acute CNS injuries. Glia 2014; 62: 1895-1904.
Costes N, Blanc C, Bouillot C, et al. Supervised clustering for determining a reference region for [11C]PK11195: Adaptation to rat PET studies. BRAIN 13, Shanghai, China, 20-23 May 2013. Available at: http://iscbfm.org/ PDFS/44/444ae58a-959f-49ab-a58c-d43c2993543c.pdf.
Gershen LD, Zanotti-Fregonara P, Dustin IH, et al. Neuroinflammation in temporal lobe epilepsy measured using positron emission tomographic imaging of translocator protein. JAMA Neurol 2015; 72: 882-888.
Su Y, Blazer TM, Snyder AZ, et al. Quantitative amyloid imaging using image-derived arterial input function. PloS One 2015; 10: e0122920.
