[en] Background: Establishment of normal reference values for glomerular filtration rate (GFR) is mandatory in nephrology. However, no data are available for measured GFR (mGFR) in Africa. Methods: GFR was measured in 237 healthy adult subjects (103 women and 134 men, mean age 34 +/- 10 years) by iohexol plasma clearance. Results: The mean mGFR was 103 +/- 17 mL/min/1.73 m 2 and the median value was 103 mL/min/1.73 m 2 (2.5th and 97.5th percentiles are 76 and 137 mL/min/1.73 m 2 , respectively). No significant difference in mGFR results was observed in patients < 40 years of age, whereas a significant decline in mGFR was observed after 40 years of age. There was no significant difference between mGFR in men and women. Conclusions: Normal GFR values and descriptions of percentiles are now available for West Africa. As in Caucasians, no significant difference was observed between men and women. Moreover, the same age-associated decline in mGFR is also observed after 40 years of age, as in Caucasians.
Disciplines :
Urology & nephrology Laboratory medicine & medical technology
Author, co-author :
Yayo, Eric
Aye, Mireille
Yao, Carine
Gnionsahe, Appolinaire
Attoungbre, Marie-Laure
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Pottel, Hans
Monnet, Dagui
DELANAYE, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Service de néphrologie
Language :
English
Title :
Measured (and estimated) glomerular filtration rate: reference values in West Africa.
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