Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays

[en] We report here an interference that has been observed with 2nd generation PTH assays (PTH2), but not with 3rd generation PTH ones (PTH3), during PTH monitoring occurring in a surgical intervention for the resection of a parathyroid adenoma. The patient was cured and calcium levels returned to normal the next day, but PTH did not decrease with PTH2 whereas it decreased by 50% with PTH3 assays during the intervention. The reason is probably a PTH fragment released by the parathyroid gland during surgery. This fragment possesses the C-terminal part of the peptide but lacks the first amino-acids and may thus be considered as a member of the non-(1–84) PTH fragments family. It has also a longer half-life than 1–84 PTH. To avoid reporting spurious results to the surgeons, we thus recommend using PTH3 assays for monitoring of intra-operative PTH. © 2017

Disciplines :

Laboratory medicine & medical technology

Author, co-author :

Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale

SCHLECK, Marie-Louise ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs Biologie clinique - Pool assistants

Souberbielle, Jean-Claude; Laboratoire d'Explorations Fonctionnelles, Hôpital Necker-Enfants malades, Paris, France

Language :

English

Title :

Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays

Publication date :

2018

Journal title :

Clinica Chimica Acta

ISSN :

0009-8981

eISSN :

1873-3492

Publisher :

Elsevier B.V.

Volume :

477

Pages :

72-73

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 09 October 2018

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Bibliography

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