Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group

Averbuch, D.; Tridello, G.; Hoek, J.; Mikulska, M.; Akan, H.; Yaňez San Segundo, L.; Pabst, T.; Özçelik, T.; Klyasova, G.; Donnini, I.; Wu, D.; Gülbas, Z.; Zuckerman, T.; Botelho De Sousa, A.; Beguin, Yves; Xhaard, A.; Bachy, E.; Ljungman, P.; De La Camara, R.; Rascon, J.; Ruiz Camps, I.; Vitek, A.; Patriarca, F.; Cudillo, L.; Vrhovac, R.; Shaw, P. J.; Wolfs, T.; O'Brien, T.; Avni, B.; Silling, G.; Al Sabty, F.; Graphakos, S.; Sankelo, M.; Sengeloev, H.; Pillai, S.; Matthes, S.; Melanthiou, F.; Iacobelli, S.; Styczynski, J.; Engelhard, D.; Cesaro, S.

doi:10.1093/cid/cix646

Article (Scientific journals)

Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group

Averbuch, D.; Tridello, G.; Hoek, J. et al.

2017 • In Clinical Infectious Diseases, 65 (11), p. 1819-1828

Peer Reviewed verified by ORBi

Permalink
https://hdl.handle.net/2268/218795

DOI
10.1093/cid/cix646

PubMed
29020364

Files (1)Send to Details Statistics Bibliography Similar publications

Files

Full Text

Bacterial resistance-Clin.Infect.dis..pdf

Publisher postprint (328.7 kB)

Download

All documents in ORBi are protected by a user license.

Send to

RIS BibTex APA Chicago Permalink X Linkedin

Details

Keywords :

Acinetobacter; Acinetobacter baumannii; Article; Asia; Australia; Enterobacteriaceae; Escherichia coli; Europe; Gram negative bacterium; Gram negative sepsis; Pseudomonas aeruginosa; Stenotrophomonas maltophilia

Abstract :

[en] Background This intercontinental study aimed to study gram-negative rod (GNR) resistance in hematopoietic stem cell transplantation (HSCT). Methods GNR bacteremias occurring during 6 months post-HSCT (February 2014-May 2015) were prospectively collected, and analyzed for rates and risk factors for resistance to fluoroquinolones, noncarbapenem anti-Pseudomonas β-lactams (noncarbapenems), carbapenems, and multidrug resistance. Results Sixty-five HSCT centers from 25 countries in Europe, Australia, and Asia reported data on 655 GNR episodes and 704 pathogens in 591 patients (Enterobacteriaceae, 73%; nonfermentative rods, 24%; and 3% others). Half of GNRs were fluoroquinolone and noncarbapenem resistant; 18.5% carbapenem resistant; 35.2% multidrug resistant. The total resistance rates were higher in allogeneic HSCT (allo-HSCT) vs autologous HSCT (auto-HSCT) patients (P <.001) but similar in community-acquired infections. Noncarbapenem resistance and multidrug resistance were higher in auto-HSCT patients in centers providing vs not providing fluoroquinolone prophylaxis (P <.01). Resistance rates were higher in southeast vs northwest Europe and similar in children and adults, excluding higher fluoroquinolone- and β-lactam/β-lactamase inhibitor resistance rates in allo-HSCT adults. Non-Klebsiella Enterobacteriaceae were rarely carbapenem resistant. Multivariable analysis revealed resistance risk factors in allo-HSCT patients: fluoroquinolone resistance: adult, prolonged neutropenia, breakthrough on fluoroquinolones; noncarbapenem resistance: hospital-acquired infection, breakthrough on noncarbapenems or other antibiotics (excluding fluoroquinolones, noncarbapenems, carbapenems), donor type; carbapenem resistance: breakthrough on carbapenem, longer hospitalization, intensive care unit, previous other antibiotic therapy; multidrug resistance: longer hospitalization, breakthrough on β-lactam/β-lactamase inhibitors, and carbapenems. Inappropriate empiric therapy and mortality were significantly more common in infections caused by resistant bacteria. Conclusions Our data question the recommendation for fluoroquinolone prophylaxis and call for reassessment of local empiric antibiotic protocols. Knowledge of pathogen-specific resistance enables early appropriate empiric therapy. Monitoring of resistance is crucial. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.

Disciplines :

Hematology

Author, co-author :

Averbuch, D.; Hadassah University Hospital, Pediatric Infectious Diseases, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Tridello, G.; Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata, Verona, Italy

Hoek, J.; European Bone Marrow Transplantation Data Office, Leiden, Netherlands

Mikulska, M.; Ospedale San Martino, Genova, Italy

Akan, H.; Faculty of Medicine, Ankara University, Turkey

Yaňez San Segundo, L.; Hospital Universitario Marqués de Valdecilla, Santander, Spain

Pabst, T.; University Hospital, Bern, Switzerland

Özçelik, T.; Florence Nightingale Sisli Hospital, Istanbul, Turkey

Klyasova, G.; National Research Center for Hematology, Moscow, Russian Federation

Donnini, I.; Azienda Ospedaliera Universitaria Careggi, Firenze, Italy

More authors (31 more)

Language :

English

Title :

Publication date :

2017

Journal title :

Clinical Infectious Diseases

ISSN :

1058-4838

eISSN :

1537-6591

Publisher :

Oxford University Press

Volume :

Issue :

Pages :

1819-1828

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 19 January 2018

Statistics

Number of views

620 (3 by ULiège)

Number of downloads

604 (1 by ULiège)

More statistics

Scopus citations^®

170

Scopus citations^®
without self-citations

137

OpenCitations

132

Bibliography

Passweg JR, Baldomero H, Bader P, et al. Use of haploidentical stem cell transplantation continues to increase: the 2015 European Society for Blood and Marrow Transplant activity survey report. Bone Marrow Transplant 2017; 52:811-7.
Girmenia C, Viscoli C, Piciocchi A, et al. Management of carbapenem resistant Klebsiella pneumoniae infections in stem cell transplant recipients: an Italian multidisciplinary consensus statement. Haematologica 2015; 100:e373-6.
Averbuch D, Cordonnier C, Livermore DM, et al. Targeted therapy against multi-resistant bacteria in leukemic and hematopoietic stem cell transplant recipients: guidelines of the 4th European Conference on Infections in Leukemia (ECIL-4, 2011). Haematologica 2013; 98:1836-47.
Mikulska M, Viscoli C, Orasch C, et al; Fourth European Conference on Infections in Leukemia Group (ECIL-4), a joint venture of EBMT, EORTC, ICHS, ELN and ESGICH/ESCMID. Aetiology and resistance in bacteraemias among adult and paediatric haematology and cancer patients. J Infect 2014; 68:321-31.
Bousquet A, Malfuson JV, Sanmartin N, et al. An 8-year survey of strains identified in blood cultures in a clinical haematology unit. Clin Microbiol Infect 2014; 20:O7-12.
Weisser M, Theilacker C, Sutter ST, et al. Secular trends of bloodstream infections during neutropenia in 15,181 haematopoietic stem cell transplants: 13-year results from a European multicentre surveillance study (ONKO-KISS). Clin Microbiol Infect 2017. doi:10.1016/j.cmi.2017.03.020.
Girmenia C, Rossolini GM, Piciocchi A, et al; Gruppo Italiano Trapianto Midollo Osseo (GITMO); Gruppo Italiano Trapianto Midollo Osseo GITMO. Infections by carbapenem-resistant Klebsiella pneumoniae in SCT recipients: a nationwide retrospective survey from Italy. Bone Marrow Transplant 2015; 50:282-8.
Satlin MJ, Cohen N, Ma KC, et al. Bacteremia due to carbapenem-resistant Enterobacteriaceae in neutropenic patients with hematologic malignancies. J Infect 2016; 73:336-45.
Mikulska M, Del Bono V, Raiola AM, et al. Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transplant 2009; 15:47-53.
Vehreschild MJ, Hamprecht A, Peterson L, et al. A multicentre cohort study on colonization and infection with ESBL-producing Enterobacteriaceae in highrisk patients with haematological malignancies. J Antimicrob Chemother 2014; 69:3387-92.
Trecarichi EM, Pagano L, Candoni A, et al; HeMABIS Registry-SEIFEM Group, Italy. Current epidemiology and antimicrobial resistance data for bacterial bloodstream infections in patients with hematologic malignancies: an Italian multicentre prospective survey. Clin Microbiol Infect 2015; 21:337-43.
Caselli D, Cesaro S, Ziino O, et al; Infection Study Group of the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). Multidrug resistant Pseudomonas aeruginosa infection in children undergoing chemotherapy and hematopoietic stem cell transplantation. Haematologica 2010; 95:1612-5.
Gudiol C, Tubau F, Calatayud L, et al. Bacteraemia due to multidrug-resistant gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes. J Antimicrob Chemother 2011; 66:657-63.
Trecarichi EM, Pagano L, Martino B, et al; Haematologic Malignancies Associated Bloodstream Infections Surveillance (HEMABIS) registry-Sorveglianza Epidemiologica Infezioni Funginein Emopatie Maligne(SEIFEM) group, Italy. Bloodstream infections caused by Klebsiella pneumoniae in onco-hematological patients: clinical impact of carbapenem resistance in a multicentre prospective survey. Am J Hematol 2016; 91:1076-81.
Wang CH, Chang FY, Chao TY, et al. Characteristics comparisons of bacteremia in allogeneic and autologous hematopoietic stem cell-transplant recipients with levofloxacin prophylaxis and influence on resistant bacteria emergence. J Microbiol Immunol Infect 2016. doi:10.1016/j.jmii.2016.02.003.
Satwani P, Freedman JL, Chaudhury S, et al. A multicenter study of bacterial blood stream infections in pediatric allogeneic hematopoietic cell transplantation recipients: the role of acute gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant 2017; 23:642-7.
Magiorakos AP, Srinivasan A, Carey RB, et al. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect 2012; 18:268-81.
Lipsitz SR, Fitzmaurice GM, Orav EJ, Laird NM. Performance of generalized estimating equations in practical situations. Biometrics 1994; 50:270-8.
Bucaneve G, Micozzi A, Menichetti F, et al; Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) Infection Program. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 2005; 353:977-87.
Leibovici L, Paul M, Cullen M, et al. Antibiotic prophylaxis in neutropenic patients: new evidence, practical decisions. Cancer 2006; 107:1743-51.
Gafter-Gvili A, Paul M, Fraser A, Leibovici L. Effect of quinolone prophylaxis in afebrile neutropenic patients on microbial resistance: systematic review and meta-analysis. J Antimicrob Chemother 2007; 59:5-22.
Liss BJ, Vehreschild JJ, Cornely OA, et al. Intestinal colonisation and blood stream infections due to vancomycin-resistant enterococci (VRE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBLE) in patients with haematological and oncological malignancies. Infection 2012; 40:613-9.
Liu CY, Lai YC, Huang LJ, et al. Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients. Bone Marrow Transplant 2011; 46:1231-9.
Kim JH, Goulston C, Zangari M, Tricot G, Boyer MW, Hanson KE. Impact of a change in antibacterial prophylaxis on bacteremia and hospitalization rates following outpatient autologous peripheral blood stem cell transplantation for multiple myeloma. Transpl Infect Dis 2014; 16:421-9.
Freifeld AG, Bow EJ, Sepkowitz KA, et al. Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 2011; 52:e56-93.
Averbuch D, Orasch C, Cordonnier C, et al. European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European Conference on Infections in Leukemia. Haematologica 2013; 98:1826-35.
Pagano L, Caira M, Trecarichi EM, et al. Carbapenemase-producing Klebsiella pneumoniae and hematologic malignancies. Emerg Infect Dis 2014; 20:1235-6.
Falagas ME, Tansarli GS, Ikawa K, Vardakas KZ. Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/ tazobactam: a systematic review and meta-analysis. Clin Infect Dis 2013; 56:272-82.
Averbuch D, Avaky C, Harit M, et al. Non-fermentative gram-negative rods bacteremia in children with cancer: a 14-year single-center experience. Infection 2017; 45:327-34.
Satlin MJ, Vardhana S, Soave R, et al. Impact of prophylactic levofloxacin on rates of bloodstream infection and fever in neutropenic patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2015; 21:1808-14.
Bock AM, Cao Q, Ferrieri P, Young JA, Weisdorf DJ. Bacteremia in blood or marrow transplantation patients: clinical risk factors for infection and emerging antibiotic resistance. Biol Blood Marrow Transplant 2013; 19:102-8.
Patriarca F, Cigana C, Massimo D, et al. Risk factors and outcomes of infections by multidrug-resistant gram-negative bacteria in patients undergoing hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2017; 23:333-9.
Mokart D, Slehofer G, Lambert J, et al. De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study. Intensive Care Med 2014; 40:41-9.
Blennow O, Ljungman P, Sparrelid E, Mattsson J, Remberger M. Incidence, risk factors, and outcome of bloodstream infections during the pre-engraftment phase in 521 allogeneic hematopoietic stem cell transplantations. Transpl Infect Dis 2014; 16:106-14.
See I, Freifeld AG, Magill SS. Causative organisms and associated antimicrobial resistance in healthcare-associated, central line-associated bloodstream infections from oncology settings, 2009-2012. Clin Infect Dis 2016; 62:1203-9.
European Centre for Disease Prevention and Control. Summary of the latest data on antibiotic resistance in the European Union. Available at: http://ecdc.europa. eu/en/eaad/Documents/antibiotics-EARS-Net-summary-2016.pdf. Accessed 7 April 2017.
European Centre for Disease Prevention and Control. Geographical distribution of antimicrobial consumption. Available at: http://ecdc.europa.eu/en/healthtopics/ antimicrobial-resistance-and-consumption/antimicrobial-consumption/ esac-net-database/Pages/geo-distribution-consumption.aspx. Accessed 7 April 2017.
European Medicines Agency. Sales of veterinary antimicrobial agents in 26 EU/ EEA countries in 2013. Available at: http://www.ema.europa.eu/docs/en-GB/ document-library/Report/2015/10/WC500195687.pdf. Accessed 7 April 2017.
Kim SB, Min YH, Cheong JW, et al. Incidence and risk factors for carbapenemand multidrug-resistant Acinetobacter baumannii bacteremia in hematopoietic stem cell transplantation recipients. Scand J Infect Dis 2014; 46:81-8.