A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege, Yannick; Malehmir, Mohsen; Healy, Marc E.; Bettermann, Kira; Lorentzen, Anna; Vucur, Mihael; Ahuja, Akshay K.; Bohm, Friederike; Mertens, Joachim C.; Shimizu, Yutaka; Frick, Lukas; Remouchamps, Caroline; Mutreja, Karun; Kahne, Thilo; Sundaravinayagam, Devakumar; Wolf, Monika J.; Rehrauer, Hubert; Koppe, Christiane; Speicher, Tobias; Padrissa-Altes, Susagna; Maire, Renaud; Schattenberg, Jorn M.; Jeong, Ju-Seong; Liu, Lei; Zwirner, Stefan; Boger, Regina; Huser, Norbert; Davis, Roger J.; Mullhaupt, Beat; Moch, Holger; Schulze-Bergkamen, Henning; Clavien, Pierre-Alain; Werner, Sabine; Borsig, Lubor; Luther, Sanjiv A.; Jost, Philipp J.; Weinlich, Ricardo; Unger, Kristian; Behrens, Axel; Hillert, Laura; Dillon, Christopher; Di Virgilio, Michela; Wallach, David; Dejardin, Emmanuel; Zender, Lars; Naumann, Michael; Walczak, Henning; Green, Douglas R.; Lopes, Massimo; Lavrik, Inna; Luedde, Tom; Heikenwalder, Mathias; Weber, Achim

doi:10.1016/j.ccell.2017.08.010

Article (Scientific journals)

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege, Yannick; Malehmir, Mohsen; Healy, Marc E. et al.

2017 • In Cancer Cell, 32 (3), p. 342-359.e10

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https://hdl.handle.net/2268/218283

DOI
10.1016/j.ccell.2017.08.010

PubMed
28898696

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Keywords :

Animals; Apoptosis; Carcinogenesis/metabolism/pathology; Carcinoma, Hepatocellular/pathology; Caspase 8/metabolism; Cell Proliferation; Cellular Senescence; Chronic Disease; Crosses, Genetic; DNA Damage; DNA Repair; Fas-Associated Death Domain Protein/metabolism; Female; Genomic Instability; Hepatectomy; Hepatocytes/pathology; Histones/metabolism; Humans; JNK Mitogen-Activated Protein Kinases/metabolism; Liver/metabolism/pathology; Liver Neoplasms/enzymology/pathology; Liver Regeneration; Male; Mice; Myeloid Cell Leukemia Sequence 1 Protein/metabolism; Phosphorylation; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism; Receptors, Tumor Necrosis Factor, Type I/metabolism; Risk Factors; DNA damage response; hepatocellular carcinoma; liver; replication stress

Abstract :

[en] Concomitant hepatocyte apoptosis and regeneration is a hallmark of chronic liver diseases (CLDs) predisposing to hepatocellular carcinoma (HCC). Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. Proliferation-associated replication stress, DNA damage, and genetic instability are detectable in CLDs before any neoplastic changes occur. Accumulated levels of hepatocyte apoptosis determine and predict subsequent hepatocarcinogenesis. Proliferation-associated DNA damage is sensed by a complex comprising caspase-8, FADD, c-FLIP, and a kinase-dependent function of RIPK1. This platform requires a non-apoptotic function of caspase-8, but no caspase-3 or caspase-8 cleavage. It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Boege, Yannick

Malehmir, Mohsen

Healy, Marc E.

Bettermann, Kira

Lorentzen, Anna

Vucur, Mihael

Ahuja, Akshay K.

Bohm, Friederike

Mertens, Joachim C.

Shimizu, Yutaka

More authors (43 more)

Language :

English

Title :

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Publication date :

2017

Journal title :

Cancer Cell

ISSN :

1535-6108

eISSN :

1878-3686

Publisher :

Cell Press, Cambridge, United States - Massachusetts

Volume :

Issue :

Pages :

342-359.e10

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 15 January 2018

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