Anti-mullerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow.
[en] The major limitation to the development of embryo production in cattle is the strong between-animal variability in ovulatory response to FSH-induced superovulation, mainly due to differences in ovarian activity at the time of treatment. This study aimed to establish whether anti-Mullerian hormone (AMH) was an endocrine marker of follicular populations in the cow, as in human, and a possible predictor of the ovarian response to superovulation. Anti-Mullerian hormone concentrations in plasma varied 10-fold between cows before treatment and were found to be highly correlated with the numbers of 3- to 7-mm antral follicles detected by ovarian ultrasonography before treatment (r=0.79, P<0.001) and the numbers of ovulations after treatment (r=0.64, P<0.01). Between-animal differences in AMH concentrations were found to be unchanged after a 3-mo delay (r=0.87, P<0.01), indicating that AMH endocrine levels were characteristic of each animal on a long-term period. The population of healthy 3- to 7-mm follicles was the main target of superovulatory treatments, contained the highest AMH concentrations and AMH mRNA levels compared with larger follicles, and contributed importantly to AMH endocrine levels. In conclusion, AMH was found to be a reliable endocrine marker of the population of small antral gonadotropin-responsive follicles in the cow. Moreover, AMH concentrations in the plasma of individuals were indicative of their ability to respond to superovulatory treatments.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Rico, Charlene; INRA-CNRS-Université de Tours-Haras Nationaux > Unité Expérimentale de Physiologie Animale de l‘Orfrasiére
Fabre, Stephane; Université de Tours-Haras Nationaux > Unité Expérimentale de Physiologie Animale de l‘Orfrasiére
Medigue, Claire; Domaine de Voluceau, 78153 Le Chesnay, France Endocrinologie et Génétique de la Reproduction et du Développement
di Clemente, Nathalie; Institut National de la Santé et de la Recherche Médicale, U782, Université Paris-Sud, UMR-S0782, F-92140 Clamart, France > Laboratory of Endocrinology and Animal Reproduction
Clement, Frederique; Domaine de Voluceau, 78153 Le Chesnay, France Endocrinologie et Génétique de la Reproduction et du Développement
Bontoux, Martine; INRA-CNRS-Université de Tours-Haras Nationaux > Physiologie de la Reproduction et des Comportements
Touze, Jean-Luc; INRA-CNRS-Université de Tours-Haras Nationaux > Physiologie de la Reproduction et des Comportements, UMR 6175
Dupont, Mickael; Centre INRA de Tours, 37380 Nouzilly, France > Centre de Recherche INRIA Paris-Rocquencourt
Briant, Eric; Centre INRA de Tours, 37380 Nouzilly, France > Centre de Recherche INRIA Paris-Rocquencourt
Remy, Benoit; Université de Liège - ULiège > Faculté de médecine vétérinaire
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Monniaux, Danielle; Physiologie de la Reproduction et des Comportements, UMR 6175 INRA-CNRS-Universite´ de Tours-Haras Nationaux
Language :
English
Title :
Anti-mullerian hormone is an endocrine marker of ovarian gonadotropin-responsive follicles and can help to predict superovulatory responses in the cow.
Publication date :
2009
Journal title :
Biology of Reproduction
ISSN :
0006-3363
eISSN :
1529-7268
Publisher :
Society for the Study of Reproduction, Madison, United States - Wisconsin
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