[en] The cyanobacterial genus Arthrospira appears very conserved and has been divided into five main genetic clusters on the basis of molecular taxonomy markers. Genetic studies of seven Arthrospira strains, including genome sequencing, have enabled a better understanding of those photosynthetic prokaryotes. Even though genetic manipulations have not yet been performed with success, many genomic and proteomic features such as stress adaptation, nitrogen fixation, or biofuel production have been characterized. Many of above-mentioned studies aimed to optimize the cultivation conditions. Factors like the light intensity and quality, the nitrogen source, or different modes of growth (auto-, hetero-, or mixotrophic) have been studied in detail. The scaling-up of the biomass production using photobioreactors, either closed or open, was also investigated to increase the production of useful compounds. The richness of nutrients contained in the genus Arthrospira can be used for promising applications in the biomedical domain. Ingredients such as the calcium spirulan, immulina, C-phycocyanin, and γ-linolenic acid (GLA) show a strong biological activity. Recently, its use in the fight against cancer cells was documented in many publications. The health-promoting action of “Spirulina” has been demonstrated in the case of cardiovascular diseases and age-related conditions. Some compounds also have potent immunomodulatory properties, promoting the growth of beneficial gut microflora, acting as antimicrobial and antiviral. Products derived from Arthrospira were shown to successfully replace biomaterial scaffolds in regenerative medicine. Supplementation with the cyanobacterium also improves the health of livestock and quality of the products of animal origin. They were also used in cosmetic preparations.
Research Center/Unit :
CIP - Centre d'Ingénierie des Protéines - ULiège
Disciplines :
Biotechnology Life sciences: Multidisciplinary, general & others Microbiology
Author, co-author :
Furmaniak, Magda
Misztak, Agnieszka
Franczuk, Martyna
Wilmotte, Annick ; Université de Liège - ULiège > Département des sciences de la vie > Physiologie et génétique bactériennes
Waleron, Malgorzata
Waleron, Krzysztof
Language :
English
Title :
Edible cyanobacterial genus Arthrospira: actual state of the art in cultivation methods, genetics and application in medicine
Alternative titles :
[fr] Le genre de cyanobactérie comestible Arthrospira: état actuel des connaissances dans les méthodes de culture, la génétique et les applications dans le domaine médical
Publication date :
18 December 2017
Journal title :
Frontiers in Microbiology
eISSN :
1664-302X
Publisher :
Frontiers Research Foundation, Lausanne, Switzerland
Volume :
8
Pages :
2541
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Arthrospira
Funders :
Medical University of Gdansk, Poland Communauté française de Belgique - CfB- WBI
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