Reference : Genome-wide association study and annotating candidate gene networks affecting age at...
Scientific journals : Article
Life sciences : Animal production & animal husbandry
http://hdl.handle.net/2268/216299
Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle
English
REIS MOTA, Rodrigo mailto [Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Ingénierie des productions animales et nutrition >]
Guimarães, S.E.F [> >]
Fortes, M.R.S. [> >]
Hayes, B. [> >]
Fonseca e Silva, Fabyano [> >]
Verardo, V. V. [> >]
Kelly, M. J. [> >]
de Campos, C. F. [> >]
Guimarães, J. D. [> >]
Wenceslau, R. R. [> >]
Penitente-Filho, J. M. [> >]
Garcia, J. F. [> >]
Moore, S. [> >]
22-Nov-2017
Journal of Animal Breeding and Genetics
Blackwell Publishing
134
6
484–492
Yes (verified by ORBi)
International
0931-2668
1439-0388
Berlin
Germany
[en] beef cattle ; gene function ; single-step
[en] We performed a genome-wide mapping for the age at first calving (AFC) with the goal of annotating candidate genes that regulate fertility in Nellore cattle. Phenotypic data from 762 cows and 777k SNP genotypes from 2,992 bulls and cows were used. Single nucleotide polymorphism (SNP) effects based on the single- step GBLUP methodology were blocked into adjacent windows of 1 Megabase (Mb) to explain the genetic variance. SNP windows explaining more than 0.40% of the AFC genetic variance were identified on chromosomes 2, 8, 9, 14, 16 and 17. From these windows, we identified 123 coding protein genes that were used to build gene networks. From the association study and derived gene networks, putative candidate genes (e.g., PAPPA, PREP, FER1L6, TPR, NMNAT1, ACAD10, PCMTD1, CRH, OPKR1, NPBWR1 and NCOA2) and transcription factors (TF) (STAT1, STAT3, RELA, E2F1 and EGR1) were strongly associated with female fertility (e.g., negative regulation of luteinizing hormone secretion, folliculogenesis and establishment of uterine receptivity). Evidence suggests that AFC inheritance is complex and controlled by multiple loci across the genome. As several windows explaining higher proportion of the genetic variance were identified on chromosome 14, further studies investigating the interaction across haplotypes to better understand the molecular architecture behind AFC in Nellore cattle should be undertaken.
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/216299
10.1111/jbg.12299

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