Article (Scientific journals)
SCENIC: single-cell regulatory network inference and clustering
Aibar, Sara; González-Blas, Carmen Bravo; Moerman, Thomas et al.
2017In Nature Methods, 14, p. 1083–1086
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Abstract :
[en] We present SCENIC, a computational method for simultaneous gene regulatory network reconstruction and cell-state identification from single-cell RNA-seq data (http://scenic.aertslab.org). On a compendium of single-cell data from tumors and brain, we demonstrate that cis-regulatory analysis can be exploited to guide the identification of transcription factors and cell states. SCENIC provides critical biological insights into the mechanisms driving cellular heterogeneity.
Disciplines :
Computer science
Biochemistry, biophysics & molecular biology
Author, co-author :
Aibar, Sara;  Katholieke Universiteit Leuven - KUL > Department of Human Genetics
González-Blas, Carmen Bravo;  Katholieke Universiteit Leuven - KUL > Department of Human Genetics
Moerman, Thomas;  Katholieke Universiteit Leuven - KUL
Huynh-Thu, Vân Anh ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Algorith. des syst. en interaction avec le monde physique
Imrichova, Hana;  Katholieke Universiteit Leuven - KUL > Department of Human Genetics
Hulselmans, Gert;  Katholieke Universiteit Leuven - KUL > Department of Human Genetics
Rambow, Florian;  Katholieke Universiteit Leuven - KUL > Department of Oncology
Marine, Jean-Christophe;  Katholieke Universiteit Leuven - KUL > Department of Oncology
Geurts, Pierre ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Algorith. des syst. en interaction avec le monde physique
Aerts, Jan;  Katholieke Universiteit Leuven - KUL
van den Oord, Joost;  Katholieke Universiteit Leuven - KUL > Department of Imaging and Pathology Translational Cell and Tissue Research
Atak, Zeynep Kalender
Wouters, Jasper;  Katholieke Universiteit Leuven - KUL > Department of Human Genetics
Aerts, Stein;  Katholieke Universiteit Leuven - KUL > Department of Human Genetics
More authors (4 more) Less
Language :
English
Title :
SCENIC: single-cell regulatory network inference and clustering
Publication date :
09 October 2017
Journal title :
Nature Methods
ISSN :
1548-7091
eISSN :
1548-7105
Publisher :
Nature Publishing Group
Volume :
14
Pages :
1083–1086
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 November 2017

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