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Pharmacological management of type 2 diabetes: what's new in 2017?

Scheen, André

2017 • In Expert Review of Clinical Pharmacology, p. 1-12

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https://hdl.handle.net/2268/216142

DOI
10.1080/17512433.2017.1376652

PubMed
28879786

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Keywords :

Cardiovascular; DPP-4 inhibitor; GLP-1 receptor agonist; SGLT2 inhibitor; kidney; metformin; new insulin

Abstract :

[en] INTRODUCTION: Novelties in the management of type 2 diabetes are dominated by the commercialisation of new glucose-lowering agents, which offer alternatives to older antidiabetic medications, and by the publication of several prospective placebo-controlled outcome trials, which demonstrated not only cardiovascular safety but also cardiovascular and renal protection with some new medications. Areas covered: Updates regarding the use of glucose-lowering agents are discussed from a clinical point of view. Some new viewpoints concern older antidiabetic agents such as metformin, sulfonylureas and glitazones whose benefit-risk balance has been revisited, especially in high risk patients. The recent data regarding DPP-4 inhibitors (gliptins) focused on the safety profile of this pharmacological class, including in patients with impaired renal function. The highlight concerns the cardiovascular (and renal) protection by some GLP-1 receptor agonists (liraglutide, semaglutide) and SGLT2 inhibitors (empagliflozin, canagliflozin) in patients with high cardiovascular risk. Finally, efficacy and safety of new combinations and advances in insulin therapy will be briefly discussed. Expert commentary: The recent data from randomized controlled trials, meta-analyses and observational real-life studies should trigger a revision of the algorithm for the treatment of hyperglycemia in type 2 diabetes, especially in patients with high cardiovascular and/or renal risk.

Disciplines :

Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition

Author, co-author :

Scheen, André ; Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

Pharmacological management of type 2 diabetes: what's new in 2017?

Publication date :

2017

Journal title :

Expert Review of Clinical Pharmacology

ISSN :

1751-2433

eISSN :

1751-2441

Publisher :

Taylor & Francis, United Kingdom

Pages :

1-12

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 16 November 2017

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772 (7 by ULiège)

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1194 (6 by ULiège)

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Scopus citations^®

19

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13

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18

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21

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