Reference : National single-step genomic method that integrates multi-national genomic information
Scientific journals : Article
Life sciences : Animal production & animal husbandry
http://hdl.handle.net/2268/216124
National single-step genomic method that integrates multi-national genomic information
English
Vandenplas, J. [> >]
Spehar, M. [> >]
Potocnik, K. [> >]
Gengler, Nicolas mailto [Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Ingénierie des productions animales et nutrition >]
Gorjanc, G. [> >]
2017
Journal of Dairy Science
American Dairy Science Association
100
1
465 - 478
Yes (verified by ORBi)
International
0022-0302
1525-3198
Champaign
IL
[en] single-step genomic BLUP ; combination ; multi-national ; genomically enhanced estimated breeding values
[en] The aim of this paper was to develop a national single-step genomic BLUP that integrates multi-national genomic estimated breeding values (EBV) and associated reliabilities without double counting dependent data contributions from the different evaluations. Simultaneous use of all data, including phenotypes, pedigree, and genotypes, is a condition to obtain unbiased EBV. However, this condition is not always fully met, mainly due to unavailability of foreign raw data for imported animals. In dairy cattle genetic evaluations, this issue is traditionally tackled through the multiple across-country evaluation (MACE) of sires, performed by Interbull Centre (Uppsala, Sweden). Multiple across-country evaluation regresses all the available national information onto a joint pedigree to obtain country-specific rankings of all sires without sharing the raw data. In the context of genomic selection, the issue is handled by exchanging sire genotypes and by using MACE information (i.e., MACE EBV and reliabilities), as a valuable source of “phenotypic” data. Although all the available data are considered, these “multi-national” genomic evaluations use multi-step methods assuming independence of various sources of information, which is not met in all situations. We developed a method that handles this by single-step genomic evaluation that jointly (1) uses national phenotypic, genomic, and pedigree data; (2) uses multi-national genomic information; and (3) avoids double counting dependent data contributions from an animal’s own records and relatives’ records. The method was demonstrated by integrating multi-national genomic EBV and reliabilities of Brown Swiss sires, included in the InterGenomics consortium at Interbull Centre, into the national evaluation in Slovenia. The results showed that the method could (1) increase reliability of a national (genomic) evaluation; (2) provide consistent ranking of all animals: bulls, cows, and young animals; and (3) increase the size of a genomic training population. These features provide more efficient and transparent selection throughout a breeding program.
http://hdl.handle.net/2268/216124
10.3168/jds.2016-11733
http://www.sciencedirect.com/science/article/pii/S0022030216308128

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