Article (Scientific journals)
The use of desflurane for neurosurgical procedures in rhesus macaque (Macaca mulatta)
Bertrand, Henri; Sandersen, Charlotte; Flecknell, Paul
2018In Laboratory Animals
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Keywords :
Anaesthesia; non-human primate; desflurane; neurosurgery
Abstract :
[en] Volatile agents are widely used to anaesthetise laboratory non-human primates as they allow a rapid induc- tion and recovery as well as an easy adjustment of the anaesthesia plan. Desflurane is currently the volatile agent with the lowest solubility in blood, and hence enables the most rapid onset of anaesthesia and most rapid recovery. This study aimed to investigate the suitability of desflurane for maintenance of general anaes- thesia in rhesus macaques undergoing elective experimental neurosurgery. Fourteen primates (five males and nine females) were sedated with ketamine (10mg kg 1) and anaesthesia was induced with propofol (usually 8mg kg 1 IV). Anaesthesia was maintained with desflurane (5.9 0.8 %) and alfentanil (0.2–0.5mg kg 1 min 1 IV). Animals were mechanically ventilated. Meloxicam (0.3mg kg 1) and methylprednisolone infusion (5.4mg kg 1 h 1) were also administered. All the primates were successfully anaesthetised and no severe complications related to the procedure or the anaesthesia regimen occurred. No major differences in physiological parameters and recovery times between the male and female groups were found. Emergence from anaesthesia was rapid (male 5.2 2.4 min; female 4.1 1.7 min) but its quality was assessed as equiva- lent to two other volatile anaesthetics, isoflurane and sevoflurane. These had previously been assessed for neuroanaesthesia in rhesus macaques. In conclusion, this study demonstrated that desflurane was suitable for maintenance of general anaesthesia for elective experimental neurosurgical procedures in rhesus maca- que. However the vasodilatory action of the desflurane may limit its use in cases of severe intracranial hypertension or systemic hypotension.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Bertrand, Henri ;  Université de Liège - ULiège > Doct. sc. vété. (paysage)
Sandersen, Charlotte  ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Anesthésiologie et réanimation vétérinaires
Flecknell, Paul
Language :
English
Title :
The use of desflurane for neurosurgical procedures in rhesus macaque (Macaca mulatta)
Publication date :
2018
Journal title :
Laboratory Animals
ISSN :
0023-6772
eISSN :
1758-1117
Publisher :
Royal Society of Medicine Services Ltd, London, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 November 2017

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